We studied the role of intracellular signal molecules PI3K, MAPK ERK1/2, and p38 in the realization of the growth potential of mesenchymal progenitor elements. Under in vitro conditions, PI3K и ERK1/2 specifi c inhibitors reduced fi broblastic colony- and cluster-formation and considerably suppressed proliferative activity of mesenchymal precursors. Blocker of p38 and protein kinase B had no effect on the function of fi broblast CFU.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 206-209, October, 2013
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Zyuz’kov, G.N., Danilets, M.G., Ligacheva, A.A. et al. Participation of PI3K, MAPK ERK1/2, and p38 in the Realization of Growth Potential of Mesenchymal Precursor Cells under In Vitro Conditions. Bull Exp Biol Med 156, 556–559 (2014). https://doi.org/10.1007/s10517-014-2395-2
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DOI: https://doi.org/10.1007/s10517-014-2395-2