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Inotropic Effect of Dopamine on Rat Heart during Postnatal Ontogeny

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of dopamine in concentrations of 10-9, 10-8, 10-7, 10-6, and 10-5 M on contraction strength of isolated myocardial strips from the right atrium and right ventricle of rats aging 21, 42, 56, and 100 days. Dopamine in a concentration of 10-9 M had a positive inotropic effect in rats of various ages. Increasing the concentration of dopamine to 10-7-10-5 M was accompanied by a negative inotropic effect on the heart.

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References

  1. A. G. Kamkin and A. A. Kamenskii, Basic and Clinical Physiology [in Russian], Moscow (2004).

  2. P. V. Sergeev, N. L. Shimanovskii, and V. I. Petrov, Receptors for Physiologically Active Substances [in Russian], Volgograd (1999).

  3. F. Amenta, Clin. Exp. Hypertens., 19, Nos. 1-2, 27–41 (1997).

    Article  CAS  PubMed  Google Scholar 

  4. F. Amenta, A. Ricci, S. K. Tayebati, and D. Zaccheo, Ital. J. Anat. Embryol., 107, No. 3, 145–167 (2002).

    CAS  PubMed  Google Scholar 

  5. C. R. Anderson, Clin. Exp. Pharmacol. Physiol., 25, No. 6, 449–452 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. C. Cavallotti, F. Nuti, P. Bruzzone, and M. Mancone, Clin. Exp. Pharmacol. Physiol., 29, Nos. 5-6, 412–418 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. N. Craft and J. B. Schwartz, Am. J. Physiol., 268, No. 4, Pt. 2, H1441–H1452 (1995).

    CAS  PubMed  Google Scholar 

  8. K. E. Jackson, M. Farias, A. S. Stanfill, and J. L. Caffrey, Auton. Neurosci., 94, Nos. 1-2, 84–92 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. O. Happola, M. Lakomy, M. Majewski, et al., Cell Tissue Res., 274, No. 1, 181–187 (1993).

    Article  CAS  PubMed  Google Scholar 

  10. K. Leineweber, R. Buscher, H. Bruck, and O. E. Brodde, Naunyn-Schmiedebergs Arch. Pharmacol., 369, No. 1, 1–22 (2004).

    Article  CAS  PubMed  Google Scholar 

  11. B. Rubi and P. Maechler, Endocrinology, 151, No. 12, 5570–5581 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. P. A. Steele, I. L. Gibbins, and J. L. Morris, J. Auton. Nerv. Syst., 56, No. 3, 191–200 (1996).

    Article  CAS  PubMed  Google Scholar 

  13. K. Wegener and W. Kummer, Acta Anat. (Basel), 151, No. 2, 112–119 (1994).

    Article  CAS  Google Scholar 

  14. A. Carlsson, Biosci. Rep., 21, No. 6, 691–710 (2001).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, Physiology, and Human Health Care, Kazan Federal University, Kazan, Russia

    G. A. Bilalova, L. M. Kazanchikova, T. L. Zefirov & F. G. Sitdikov

Authors
  1. G. A. Bilalova
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  2. L. M. Kazanchikova
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  3. T. L. Zefirov
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  4. F. G. Sitdikov
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Corresponding author

Correspondence to G. A. Bilalova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 136-139, August, 2013

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Bilalova, G.A., Kazanchikova, L.M., Zefirov, T.L. et al. Inotropic Effect of Dopamine on Rat Heart during Postnatal Ontogeny. Bull Exp Biol Med 156, 173–176 (2013). https://doi.org/10.1007/s10517-013-2303-1

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  • DOI: https://doi.org/10.1007/s10517-013-2303-1

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