Transplantation of human mesenchymal multipotent stromal cells improved spatial memory in bulbectomized mice with Alzheimer-type neurodegeneration. The positive effect was observed in 1 month after intracerebral transplantation and in 3 months after systemic injection of mesenchymal multipotent stromal cells. No cases of malignant transformation were noted. These findings indicate prospects of using mesenchymal multipotent stromal cells for the therapy of Alzheimer disease and the possibility of their systemic administration for attaining the therapeutic effect.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 123-126, July, 2013
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Bobkova, N.V., Poltavtseva, R.A., Samokhin, A.N. et al. Therapeutic Effect of Mesenchymal Multipotent Stromal Cells on Memory in Animals with Alzheimer-Type Neurodegeneration. Bull Exp Biol Med 156, 119–121 (2013). https://doi.org/10.1007/s10517-013-2293-z
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DOI: https://doi.org/10.1007/s10517-013-2293-z