Dose-dependent effects of dexamethasone on activation and proliferation of donor immune memory T cells (CD45RO+) were studied. Activation of memory T cells associated with IL-2 production and membrane expression of CD25 molecule was resistant to dexamethasone. Proliferative activity of memory T cells associated with membrane expression of CD71 molecule was highly sensitive to dexamethasone. Hence, glucocorticoid hormones can maintain the clonal balance in the lymphoid tissue without preventing realization of the immune memory mechanism.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 4, pp. 468-470, April, 2013
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Gutsol, A.A., Sokhonevich, N.A., Seledtsov, V.I. et al. Dexamethasone Effects on Activation and Proliferation of Immune Memory T Cells. Bull Exp Biol Med 155, 474–476 (2013). https://doi.org/10.1007/s10517-013-2182-5
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DOI: https://doi.org/10.1007/s10517-013-2182-5