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Antioxidant Properties of Pyrrolobenzimidazole Derivative RU-792: Experimental Study

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied antioxidant activity of new derivative of pyrrolo[1,2-α]benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical properties. RU-792 was superior to Trolox by antioxidant activity in the models of Fe2+-induced chemiluminescence of lipids with 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), but less effective in the model of luminol-dependent chemiluminescence.

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Authors and Affiliations

  1. Department of Pharmacology, Volgograd State Medical Academy, Volgograd, Russia

    V. A. Kosolapov & A. A. Spasov

  2. Laboratory of Pharmacology of Antioxidant Substances, Institute of Pharmacology, Volgograd State Medical Academy, Volgograd, Russia

    V. A. Kosolapov & L. V. Eltsova

  3. Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    V. A. Anisimova

Authors
  1. V. A. Kosolapov
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  2. L. V. Eltsova
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  3. A. A. Spasov
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  4. V. A. Anisimova
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Correspondence to V. A. Kosolapov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 4, pp. 453-456, April, 2013

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Kosolapov, V.A., Eltsova, L.V., Spasov, A.A. et al. Antioxidant Properties of Pyrrolobenzimidazole Derivative RU-792: Experimental Study. Bull Exp Biol Med 155, 461–463 (2013). https://doi.org/10.1007/s10517-013-2178-1

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  • DOI: https://doi.org/10.1007/s10517-013-2178-1

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