Skip to main content
SpringerLink
Log in

Cytokine Levels in Rat Blood and Brain Structures after Administration of Lipopolysaccharide

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We compared cytokine profi le of rat serum and brain structures after immune status modulation by LPS (30 μg/kg intraperitoneally). The content of infl ammatory (IL-1α, IL-1β, IL-2, IL-6, IFN-γ, and TNF-α) and anti-infl ammatory (IL-4 and IL-10) cytokines in biological samples of animals was measured on days 1 and 7 after antigenic stimulation. LPS administration reduced the levels of both infl ammatory and anti-infl ammatory cytokines in the peripheral blood of the rats, especially on the 1st day. LPS administration was also accompanied by specifi c changes in cytokine content in the dorsal hippocampus and anterior cingulate cortex. Antigenic stimulation increased the level of anti-infl ammatory cytokines IL-4 and IL-10 in the examined brain tissues, the changes were most pronounced on day 1 after LPS injection. No signifi cant changes in the levels of proinfl ammatory cytokines in the brain tissue of animals were found at the above terms after LPS injection. Thus, peripheral LPS administration to rats shifts the balance between the infl ammatory and anti-infl ammatory cytokines in the CNS structures towards the latter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yu. B. Abramov, A. Yu. Kozlov, E. V. Nikenina, and E. G. Ionkina, Bol’, 22, No. 1, 15-18 (2009).

    Google Scholar 

  2. M. M. Gevorkyan, S. M. Kuznetsova, and E. L. Alperina, Byull. SO RAMN, 30, No. 4, 38-41 (2010).

    Google Scholar 

  3. C. A. Ketlinsky and A. S. Simbirtsev, Cytokines [in Russian], St. Petersburg (2008).

  4. S. V. Magaeva and S. G. Morozov, Neuroimmunophysiology [in Russian], Moscow (2005), pp. 158.

  5. Y. B. Abramov, A. Y. Kozlov, O. S. Sinel’shchikova, and G. V. Torgovanova, Neurosci. Behav. Physiol., 33, No. 8, 821 (2003).

    Article  PubMed  Google Scholar 

  6. Z. Bekker, A. Walubo, and J. B. du Plessis, ISRN Pharm., (2012). Published online 2012 August 16. doi: 10.5402/2012/932542.

  7. H. D. Brightbill and R. L. Modlin, Immunology, 101, No. 1, 1-10 (2000).

    Article  PubMed  CAS  Google Scholar 

  8. M. Buttini and H. Boddeke, Neuroscience, 65, No. 2, 523-530 (1995).

    Article  PubMed  CAS  Google Scholar 

  9. Y. Delneste, C. Beauvillain, and P. Jeannin, Med. Sci. (Paris), 23, No. 1, 67-73 (2007).

    Article  Google Scholar 

  10. R. S. Devi, R. M. Sivaprakash, and A. Namasivayam, Indian J. Physiol. Pharmacol., 48, No. 3, 329-336 (2004).

    PubMed  Google Scholar 

  11. T. Kaisho and S. Akira, Microbes Infect., 6, No. 15, 1388-1394 (2004).

    Article  PubMed  CAS  Google Scholar 

  12. A.Yu. Kozlov, A.Yu. Abramova, E.V. Nikenina, and L.V. Mezentseva, Bull. Exp. Biol. Med., 153, No. 5, 730-733 (2012).

    Article  PubMed  CAS  Google Scholar 

  13. R. Medzhitov and C. A. Fr. Janeway, Cell, 91, No. 3, 295-298 (1997).

    Article  PubMed  CAS  Google Scholar 

  14. W. Ren, L. Hu, F. Hua, et al., Immunol. Lett., 141, No. 1, 94-101 (2011).

    Article  PubMed  CAS  Google Scholar 

  15. H. Shimauchi, T. Ogawa, K. Okuda, et al., Infect. Immun., 67, No. 5, 2153-2159 (1999).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia

    A. Yu. Abramova, S. S. Pertsov, A. Yu. Kozlov, E. V. Nikenina, L. S. Kalinichenko, E. N. Dudnik & I. V. Alekseeva

Authors
  1. A. Yu. Abramova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. S. Pertsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Yu. Kozlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. V. Nikenina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. S. Kalinichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. N. Dudnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. V. Alekseeva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Yu. Abramova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 4, pp. 405-409, April, 2013

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abramova, A.Y., Pertsov, S.S., Kozlov, A.Y. et al. Cytokine Levels in Rat Blood and Brain Structures after Administration of Lipopolysaccharide. Bull Exp Biol Med 155, 417–420 (2013). https://doi.org/10.1007/s10517-013-2166-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-013-2166-5

Keywords

Search

Navigation