The structure and functions of endothelial cells after space mission were studied by electron and laser confocal microscopy, image analysis, and MTT test. The endothelial cells changed signifi cantly (proliferative activity, size, contours, shape, distribution of mitochondria and microtubules) in comparison with controls on the Earth. These changes indicated injuries in the cytoskeleton and impairment of the barrier function of the cells, which presumably contributed to the development of endothelial dysfunction.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 12, pp. 766-771, December, 2012
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Kapitonova, M.Y., Kuznetsov, S.L., Froemming, G.R.A. et al. Effects of Space Mission Factors on the Morphology and Function of Endothelial Cells. Bull Exp Biol Med 154, 796–801 (2013). https://doi.org/10.1007/s10517-013-2059-7
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DOI: https://doi.org/10.1007/s10517-013-2059-7