Protein kinase C blocker chelerythrine prevented the increase in quantal content of single and rhythmic evoked end-plate potentials after disinhibition of L-type Ca2+-channels with paxillin. Phorbol ester increased quantal content of single end-plate potentials and changed rhythmic activity of mouse motor synapses. The effects of phorbol ester were to a great extent neutralized by L-type Ca2+-channel blocker nitrendipine and were completely abolished by К+-channel blocker 4-aminopyridine. Thus, we discovered different facilitations of transmission after protein kinase C activation with calcium current through L-type channels and with phorbol ester.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 4, pp. 400-404, April, 2012
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Gaydukov, A.E., Marchenkova, A.A. & Balezina, O.P. Facilitation of Neurotransmitter Release in Mouse Motor Synapses in Different Modes of Protein Kinase C Activation. Bull Exp Biol Med 153, 415–418 (2012). https://doi.org/10.1007/s10517-012-1729-1
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DOI: https://doi.org/10.1007/s10517-012-1729-1