Immunohistochemical studies revealed increased level of matrix metalloproteinase 9 in skin melanoma cells. Inhibition of matrix metalloproteinase 9 with interfering RNA changed the level of PCNA and reduced N-cadherin content in melanoma cells. This attests to the involvement of matrix metalloproteinase 9 in the realization of invasion and metastatic growth and in the regulation of tumor growth and progress.
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References
K. M. Conolly and M. S. Bogdanffy, Cytochem., 41, No. 1, 1–6 (1993).
D. R. Dietrich, Crit. Rev. Toxicol., 23, No. 1, 77–109 (1993).
A. Dwivedi, S. C. Slater, and S. J. George, Cardiovasc. Res., 81, No. 1, 178–186 (2009).
A. R. Folgueras, A. M. Pendas, L. M. Sunchez, et al., Int. J. Dev. Biol., 48, Nos. 5–6, 411–424 (2004).
E. Hijova, Bratisl. Lek. Listy, 106, No. 3, 127–132 (2005).
M. Illemann, N. Bird, A. Majeed, et al., Mol. Cancer Res., 4, No. 5, 293–302 (2006).
E. Meyer, J. Y. Vollmer, R. Bovey, and I. Stamenkovic, Cancer Res., 65, No. 10, 4261–4272 (2005).
T. Nakamura, T. Hayashi, Y. Nasu-Nishumura, et al., Genes. Dev., 22, No. 9, 1244–1256 (2008).
Y. G. Shellman, M. Makela, and D. A. Norris, Melanoma Res., 16, No. 3, 207–211 (2006).
M. D. Sternlicht and Z. Werb, Annu. Rev. Cell Dev. Biol., 17, 463–516 (2001).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 3, pp. 343-345, March, 2012
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Aksenenko, M.B., Gyrylova, S.N. & Ruksha, T.G. Changes in the Levels of N-Cadherin and PCNA in Skin Melanoma Cells Are Mediated through Matrix Metalloproteinase 9. Bull Exp Biol Med 153, 364–366 (2012). https://doi.org/10.1007/s10517-012-1717-5
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DOI: https://doi.org/10.1007/s10517-012-1717-5