We studied the effect of Fe2+ on hemolysin synthesis by Staphylococcus aureus. Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe2+ was followed by an increase in hemolytic activity of staphylococci. Inducible synthesis of α-hemolysin probably serves as an important pathogenetic factor in the development of staphylococcal infection in patients with excessive iron accumulation in the body.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 1, pp. 49-51, January, 2012
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Leonov, V.V., Kosterina, V.V., Varnitsina, V.V. et al. Iron-Dependent Synthesis of Hemolysins by Staphylococcus aureus . Bull Exp Biol Med 153, 41–43 (2012). https://doi.org/10.1007/s10517-012-1645-4
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DOI: https://doi.org/10.1007/s10517-012-1645-4