The effects of histamine and mechanisms of its action on the capsular smooth muscle cells of mesenteric lymph nodes were examined on isolated capsular strips under isometric conditions. Histamine (1 × 10-8-5 × 10-7 M) decreased the tone of capsular smooth muscle cells and the frequency of phasic contractions. At high concentrations (more than 5 × 10-6 M), histamine increased the amplitude and frequency of phasic contractions against the background of increased tonic stress. The effects of histamine were dose-dependent and were realized via direct stimulation of H1- and H2-receptors on the membrane of smooth muscle cells.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 10, pp. 384-386, October 2011
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Lobov, G.I., Pan’kova, M.N. Effect of Histamine on Contractile Activity of Smooth Muscles in Bovine Mesenteric Lymph Nodes. Bull Exp Biol Med 152, 406–408 (2012). https://doi.org/10.1007/s10517-012-1539-5
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DOI: https://doi.org/10.1007/s10517-012-1539-5