The development of a depression-like state in C57Bl/6J mice with repeated defeat experience (10 and 20 days) was accompanied by inhibition of the immune response (evaluated from the number of IgM antibody-producing cells). Activation of postsynaptic 5-HT1A receptors with a selective agonist 8-OH-DPAT (1.0 mg/kg) in these animals had no effect on the immune reaction. In mice without the experience of confrontations, stimulation of postsynaptic receptors caused a decrease in the number of IgM antibody-producing cells at the peak of the immune response induced by sheep erythrocytes (5 × 108 cells). However, the count of these cells remained unchanged in mice with a depression-like state (irrespective of the stage of disorder). Activation of presynaptic 5-HT1A receptors with 8-OH-DPAT (0.1 mg/kg) in control animals and mice with 10-day defeat experience was followed by immune stimulation. These changes were not observed in mice with a depression-like state caused by 20-day social stress.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 3, pp. 331–333, March, 2011
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Idova, G.V., Jur’ev, D.V., Zhukova, E.N. et al. Immune Response during Activation of Pre- and Postsynaptic Serotonin 5-HT1A Receptors in C57Bl/6J Mice at Various Stages of a Depression-Like State. Bull Exp Biol Med 151, 356–358 (2011). https://doi.org/10.1007/s10517-011-1329-5
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DOI: https://doi.org/10.1007/s10517-011-1329-5