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Effect of Epithermal Neutrons on Viability of Glioblastoma Tumor Cells in Vitro

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We studied in vitro effect of epithermal neutrons in various doses on viability of glioblastoma U87 tumor cells. Increasing the dose from 1.9 to 4.1 Sv promoted cell death. Cytofluorimetric analysis revealed no activation of apoptosis in the irradiated cells, which attested to necrotic death of the tumor cells exposed to epithermal neutron radiation.

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References

  1. A. S. Kuznetsov, G. N. Malyshkin, A. N. Makarov, et al., Pism. Zh. Teor. Fiz., 35, No. 8, 1–6 (2009).

    Google Scholar 

  2. B. Bayanov, V. Belov, E. Bender, et al., Nucl. Instr. Meth. Phys. Res., Sec. A, 413, Nos. 2–3, 397–426 (1998).

    Article  CAS  Google Scholar 

  3. Y. Fujita, I. Kato, S. Iwai, et al., Radiat. Oncol., 4, 63 (2009).

    Article  PubMed  Google Scholar 

  4. N. Fuwa, M. Suzuki, Y. Sakurai, et al., Br. J. Radiol., 81, No. 969, 749–752 (2008).

    Article  PubMed  CAS  Google Scholar 

  5. A. Kamida, Y. Fujita, I. Kato, et al., J . Radiat. Biol., 84, No.3, 191–199 (2008).

    Article  CAS  Google Scholar 

  6. E. B. Kullberg, Q. Wei, J. Capala, et al., Int. J. Radiat. Biol., 81, No.8, 621–629 (2005).

    Article  PubMed  CAS  Google Scholar 

  7. U. Linz, Technol. Cancer. Res. Treat., 7, No. 1, 83–88 (2008).

    PubMed  CAS  Google Scholar 

  8. M. A. Pisarev, M. A. Dagrosa, and G. J. Juvenal, Arq. Bras. Endocrinol. Metabol., 51, No. 5, 852–856 (2007).

    Article  PubMed  Google Scholar 

  9. M. Suzuki, H. Tanaka, Y. Sakurai, et al., Radiother. Oncol., 92, No. 1, 89–95 (2009).

    Article  PubMed  CAS  Google Scholar 

  10. C. M. van Rij, A. J. Wilhelm, W. A. Sauerwein, et al., Pharm. World Sci., 27, No. 2, 92–95 (2005).

    Article  PubMed  Google Scholar 

  11. T. Yamamoto, K. Nakai, and A. Matsumura, Cancer Lett., 262, No. 2, 143–152 (2008).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    L. A. Mostovich, O. S. Kutsenko & E. V. Grigor’eva

  2. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    N. V. Gubanova

  3. Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    V. I. Aleinik, A. S. Kuznetsov, A. N. Makarov, I. N. Sorokin & S. Yu. Taskaev

  4. Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    G. I. Nepomnyashchikh

Authors
  1. L. A. Mostovich
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  2. N. V. Gubanova
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  3. O. S. Kutsenko
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  4. V. I. Aleinik
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  5. A. S. Kuznetsov
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  6. A. N. Makarov
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  7. I. N. Sorokin
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  8. S. Yu. Taskaev
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  9. G. I. Nepomnyashchikh
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  10. E. V. Grigor’eva
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Corresponding author

Correspondence to L. A. Mostovich.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 02, pp. 229–233, February 2011

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Mostovich, L.A., Gubanova, N.V., Kutsenko, O.S. et al. Effect of Epithermal Neutrons on Viability of Glioblastoma Tumor Cells in Vitro . Bull Exp Biol Med 151, 264–267 (2011). https://doi.org/10.1007/s10517-011-1304-1

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  • DOI: https://doi.org/10.1007/s10517-011-1304-1

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