We compared the effects of NF-κB inhibitor aurothiomalate and voltaren on NO production by mouse macrophages in vitro, their ability to cause local edema at the site of injection, and their effect on carrageenan-induced inflammation. High concentrations of aurothiomalate reduced NO production, while in low concentrations both aurothiomalate and voltaren stimulated this process. When injected into mouse footpad, aurothiomalate in a dose >1 mM and voltaren in a dose >1.6 μM induce paw edema. Both compounds suppressed carrageenan-induced inflammation, but the efficacy of aurothiomalate 2-fold exceeded that of voltaren.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 2, pp. 153–156, February, 2011
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Belsky, Y.P., Ivanova, A.N., Danilets, M.G. et al. Study of Anti-Inflammatory Action of Aurothiomalate, an Inhibitor of NF-κB. Bull Exp Biol Med 151, 190–193 (2011). https://doi.org/10.1007/s10517-011-1286-z
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DOI: https://doi.org/10.1007/s10517-011-1286-z