Various methods were proposed for phenotyping of patients by activity of cytochrome P450 1A2, each has some advantages and disadvantages. However, no reference parameters were developed for measuring CYP1A2 activity that could be used as a unified standard for phenotyping of patients. We propose a mathematic model of caffeine metabolism allowing calculation of rate constants for the formation of its primary metabolites. First-order rate constant of paraxanthine formation was tested as a new specific marker of isoenzyme 1A2 in healthy volunteers.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. A. Filimonova, Klin. Lab. Diagn., No. 10, 34–36 (2008).
M. A. Butler, N. P. Lang, J. F. Joung, et al., Pharmacogenetics, 2, No. 3, 116–127 (1992).
J. A. Carrillo, M. Christensen, S. I. Ramos, et al., Ther. Drug. Monit., 22, No. 4, 409–417 (2000).
L. M. Christensen, Clin. Pharmacol. Ther., 74, No. 2, 144 (2003).
A. Catteau, Y. C. Bechtel, N. Poisson, et al., Eur. J. Clin. Pharmacol., 47, 423–430 (1995).
M. L. Dahl, Clin. Pharmacokinet., 41, No. 7, 453–470 (2002).
W. A. Daniel, M. Kot, and J. Wojcikowski, Pol. J. Pharmacol., 55, No. 6, 1045–1053 (2003).
M. S. Faber, A. Jetter, and U. Fuhr, Basic Clin. Pharmacol. Toxicol., 97, No. 3, 125–134 (2005).
U. Fuhr and K. L. Rost, Pharmacogenetics, 4, No. 3, 109–116 (1994).
J. Jodynis-Liebert, J. Flieger, A. Matuszewska, and J. Juszczyk, J. Clin. Pharmacol., 44, No. 4, 338–347 (2004).
A. C. Parker, P. Pritchard, T. Preston, and I. Choonara, Br. J. Clin. Pharmacol., 45, No. 2, 176–178 (1998).
K. L. Shirley, Y. Y. Hon, S. R. Penzar, et al., Neuropsychopharmacology, 28, No. 5, 961–966 (2003).
B. Sinués, M. A. Sáenz, J. Lanuza, et al., Cancer Epidemiol. Biomarkers Prev., 8, No. 2, 159–166 (1999).
B. K. Tang, Y. Zhou, D. Kadar, and W. Kalow, Pharmacogenetics, 4, No. 3, 117–124 (1994).
W. Tassaneeyakul, D. J. Birkett, M. E. McManus, et al., Biochem. Pharmacol., 47, No. 10, 1767–1776 (1994).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 12, pp. 712-714, December, 2010
Rights and permissions
About this article
Cite this article
Filimonova, A.A., Ziganshina, L.E., Ziganshin, A.U. et al. New Specific Marker of Cytochrome P450 1A2 Activity. Bull Exp Biol Med 150, 762–764 (2011). https://doi.org/10.1007/s10517-011-1243-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-011-1243-x