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Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.

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Authors and Affiliations

  1. N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

    V. V. Sobolev, A. D. Zolotorenko & A. G. Soboleva

  2. Center of Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

    A. M. Elkin, S. A. Il’ina & A. L. Piruzyan

  3. I. M. Sechenov Moscow Medical Academy, Moscow, Russia

    D. N. Serov, N. N. Potekaev, S. B. Tkachenko & M. T. Minnibaev

Authors
  1. V. V. Sobolev
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  2. A. D. Zolotorenko
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  3. A. G. Soboleva
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  4. A. M. Elkin
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  5. S. A. Il’ina
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  6. D. N. Serov
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  7. N. N. Potekaev
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  8. S. B. Tkachenko
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  9. M. T. Minnibaev
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  10. A. L. Piruzyan
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Corresponding author

Correspondence to A. L. Piruzyan.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 564–566, November, 2010

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Sobolev, V.V., Zolotorenko, A.D., Soboleva, A.G. et al. Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process. Bull Exp Biol Med 150, 632–634 (2011). https://doi.org/10.1007/s10517-011-1208-0

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  • DOI: https://doi.org/10.1007/s10517-011-1208-0

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