The effect of MK-801, an antagonist to NMDA-glutamate receptors, on reconsolidation of olfactory discrimination task in rats and taste discrimination in edible snails was examined. Twenty-four hours after conditioning, the animals received a single systemic injection of MK-801 followed by a reminding conditional stimulus. Disturbances in retrieval of the acquired task were observed 10 days after injection followed by a reminding procedure. Repeated conditioning of these animals did not restore the task. Injection of MK-801 without reminding stimulation had no effect on task retention. Thus, disturbances of NMDA-dependent reconsolidation of the associative memory in animals of different taxonomic groups irreversibly eliminated long-term memory.
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References
S. A. Solntseva, V. P. Nikitin, S. A. Kozyrev, et al., Ross. Physiol. Zh., 92, No. 9, 1058-1068 (2006).
V. V. Sherstnev, V. V. Yurasov, Z. I. Storozheva, et al., Zh. Vyssh. Nerv. Deyat., 55, No. 6, 729-733 (2005).
K. V. Anokhin, A. A. Tiunova, and S. P. R. Rose, Eur. J. Neurosci., 15, No. 11, 1759-1765 (2002).
P. M. Balaban, Prog. Neurobiol., 41, 1-19 (1993).
D. T. Balu and I. Lucki, Neurosci. Biobehav. Rev., 33, No. 3, 232-252 (2009).
Z. Cui, K. A. Lindl, B. Mei, et al., Eur. J. Neurosci., 22, No. 3, 755-763 (2005).
Y. Dudai, Annu. Rev. Psychol., 55, 51-86 (2004).
R. D. Hawkins, E. R. Kandel, and C. H. Bailey, Biol. Bull., 210, No. 3, 174-191 (2006).
M. Hу, Y. J. Sun, Q. G. Zhou, et al., J. Neurochem., 106, No. 4, 1900-1913 (2008).
K. Nader and S. H. Wang, Learn. Mem., 13, No. 5, 530-553 (2006).
M. E. Pedreira, L. M. Perez-Cuesta, and H. Maldonado, J. Neurosci., 22, No. 18, 8305-8311 (2002).
A. Routtenberg, Learn Mem., 89, No. 3, 225-233 (2008).
M. Torras-Garcia, J. Lelong, S. Tronel, and S. J. Sara, Ibid., 12, No. 1, 18-22 (2005).
N. C. Tronson and J. R. Taylor, Nat. Rev. Neurosci., 8, No. 4, 262-275 (2007).
L. Zhou, A. M. Welsh, D. Chen, and V. E. Koliatsos, Neuropharmacol., 52, No. 7, 1528-1537 (2007).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 9, pp. 253-264, September, 2010
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Storozheva, Z.I., Solntseva, S.V., Nikitin, V.P. et al. Irreversible Amnesia in Rats and Edible Snails under Conditions of Associative Memory Reconsolidation Disturbance Caused by NMDA-Glutamate Receptor Antagonist. Bull Exp Biol Med 150, 286–290 (2011). https://doi.org/10.1007/s10517-011-1124-3
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DOI: https://doi.org/10.1007/s10517-011-1124-3