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Biocompatibility of Tissue Engineering Constructions from Porous Polylactide Carriers Obtained by the Method of Selective Laser Sintering and Bone Marrow-Derived Multipotent Stromal Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the biocompatibility of porous polylactide carrier matrices obtained by means of surface selective laser sintering. Carrier matrices had no cytotoxic activity, but maintained adhesion and proliferation of cells. Subcutaneous transplantation of tissue engineering constructions from these carriers and bone marrow-derived multipotent stromal cells did not cause the inflammatory response and pathological changes in rats. The conditions for organotypic regeneration were provided at the site of transplantation (high degree of blood supply and considerable amount of immature precursor cells).

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Authors and Affiliations

  1. ReMeTeks Closed Corporation, Moscow, Russia

    T. B. Bukharova, T. Kh. Fatkhudinov, A. V. Volkov & D. V. Gol’dshtein

  2. Institute for Problems of Laser and Information Technologies, Russian Academy of Sciences, Troitsk, Moscow Region, Russia

    E. N. Antonov, V. K. Popov, A. V. Popova, S. A. Bochkova & V. N. Bagratashvili

  3. Medical Genetic Research Center, Syracure, NY, USA

    T. B. Bukharova & D. V. Gol’dshtein

  4. Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia

    T. Kh. Fatkhudinov & A. V. Volkov

Authors
  1. T. B. Bukharova
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  2. E. N. Antonov
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  3. V. K. Popov
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  4. T. Kh. Fatkhudinov
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  5. A. V. Popova
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  6. A. V. Volkov
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  7. S. A. Bochkova
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  8. V. N. Bagratashvili
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  9. D. V. Gol’dshtein
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Corresponding author

Correspondence to T. B. Bukharova.

Additional information

Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 1, pp. 40-46, January, 2010

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Bukharova, T.B., Antonov, E.N., Popov, V.K. et al. Biocompatibility of Tissue Engineering Constructions from Porous Polylactide Carriers Obtained by the Method of Selective Laser Sintering and Bone Marrow-Derived Multipotent Stromal Cells. Bull Exp Biol Med 149, 148–153 (2010). https://doi.org/10.1007/s10517-010-0895-2

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  • DOI: https://doi.org/10.1007/s10517-010-0895-2

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