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Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

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Bulletin of Experimental Biology and Medicine Aims and scope

The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specifi c activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the content of regulatory proteasomal complex PA28. In the presence of regional metastases, 26S proteasome activity decreases and the content of proteasome immune subunit LMP7 in the tumor increases.

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Authors and Affiliations

  1. Research Institute of Oncology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    L. V. Spirina, I. V. Kondakova, E. L. Choinzonov, S. Y. Chigevskay & D. A. Shishkin

  2. N. K. Kol’tsov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia

    N. P. Sharova

Authors
  1. L. V. Spirina
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  2. I. V. Kondakova
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  3. E. L. Choinzonov
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  4. N. P. Sharova
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  5. S. Y. Chigevskay
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  6. D. A. Shishkin
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Corresponding author

Correspondence to L. V. Spirina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 89-92, January 2010

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Spirina, L.V., Kondakova, I.V., Choinzonov, E.L. et al. Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas. Bull Exp Biol Med 149, 82–85 (2010). https://doi.org/10.1007/s10517-010-0881-8

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  • DOI: https://doi.org/10.1007/s10517-010-0881-8

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