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Activity of Some Enzymes in the Liver of Experimental Animals after Treatment with the Liposomal Formulation of Tetracycline and Streptomycin

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

A new method for obtaining the liposomal formulation of streptomycin and tetracycline is described in the present work. The physicochemical properties of this formulation were evaluated. We compared the effects of free and liposomal formulations from streptomycin and tetracycline on activity of liver enzymes in albino mice. Immobilization of antibiotics in liposomes was followed by a decrease in the inhibitory effect on protease, alkaline phosphatase, and phosphorylase. The infl uence of this preparation on ATPase was reduced by 2 times.

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Authors and Affiliations

  1. Volgograd Antiplague Institute, Russian Agency for Health and Consumer Rights, Volgograd, Russia

    S. N. Tikhonov, K. A. Rotov, V. V. Alekseev, E. A. Snatenkov & N. P. Khrapova

Authors
  1. S. N. Tikhonov
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  2. K. A. Rotov
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  3. V. V. Alekseev
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  4. E. A. Snatenkov
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  5. N. P. Khrapova
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Corresponding author

Correspondence to N. P. Khrapova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 53–55, January, 2010

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Tikhonov, S.N., Rotov, K.A., Alekseev, V.V. et al. Activity of Some Enzymes in the Liver of Experimental Animals after Treatment with the Liposomal Formulation of Tetracycline and Streptomycin. Bull Exp Biol Med 149, 47–49 (2010). https://doi.org/10.1007/s10517-010-0872-9

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  • DOI: https://doi.org/10.1007/s10517-010-0872-9

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