Histological, morphometric, and immunohistochemical analysis showed that the specific features of epidermal barrier structure in patients with undifferentiated connective tissue dysplasia syndrome are increases number of keratinocyte rows in the basal and prickly layer as a result of their higher mitotic activity, increased numerical density of Langerhans cells, and suppression of terminal keratinocyte differentiation.
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References
G. G. Avtandilov, Medical Morphometry [in Russian], Moscow (1990).
Yu. I. Barashnev, B. V. Shekhonin, A. N. Semiachkina, K. M. Makkaev, Vopr. Okhrany Materinstva i Detstva, No. 11, 59-64 (1988).
Z. S. Barkagan, Hemorrhagic Diseases and Syndromes [in Russian], Moscow (1988).
T. I. Kadurina and V. N. Gorbunova. Connective Tissue Dysplasia [in Russian], St. Petersburg (2009).
N. V. Kungurov, N. M. Gerasimova, and M. M. Kokhan. Atopic Dermatitis: Types of Treatment, Principles of Therapy [in Russian], Ekaterinburg (2000).
N. G. Luzgina and V. A. Shkurupy, Ross. Zh. Kozhn. i Venerich. Bolezn., No. 2, 19-22 (2005).
G. A. Merkulov, Course of Pathohistilogical Technique [in Russian], Leningrad (1969).
O. V. Potapova, N. G. Luzgina, and V. A. Shkurupy, Bull. Exp. Biol. Med., Suppl. 1, 70-73 (2008).
V. V. Terskih, A. V. Vasiliev, and E. A. Voroteliak, Izv. Ross. Akad. Nauk, 6, 645-649 (2003).
V. A. Shkurupy, K. O. Samoilov, and G. N. Vereschagina, Chronic Catarrhal Gingivitis, Arterial Hypertension and Connective Tissue Dysplasia [in Russian], Novosibirsk (2001).
P. H. Beighton and F. T. Horan, J. Bone Jt. Surg., 51, 444-453 (1969).
N. Maas-Szabowski, A. Shimotoyodome, and N. E. Fusenig, J. Cell Sci., 112, Pt. 12, 1843-1853 (1999).
J. Segre, J. Clin. Invest., 116, No. 5, 1150-1158 (2006).
J. Steiberg, Am. J. Roentgenol., 97, No. 1, 118-124 (1966).
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Translated from Byulleten’ Experimental’noi Biologii i Meditsiny, Vol. 148, No. 12, p. 690-692, December, 2009
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Luzgina, N.G., Potapova, O.V., Gontsova, A.A. et al. Structural Peculiarities of Epidermal Barrier in Individuals with Syndrome of Undifferentiated Connective Tissue Dysplasia. Bull Exp Biol Med 148, 927–929 (2009). https://doi.org/10.1007/s10517-010-0854-y
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DOI: https://doi.org/10.1007/s10517-010-0854-y