Immunohistochemical study of marker expression in primary tumors of patients with esophageal squamous-cell carcinoma was carried out in order to evaluate prognostic significance of EGFR and HER-2 levels in the tumors. Hyperexpression of EGFR and HER-2 in the tumors is an important marker for the analysis of prognosis and clinical course of the disease. A relationship between high levels of EGFR and HER-2 in the tumors of patients with esophageal squamous-cell carcinoma and intravascular tumor invasion (p=0.038) and poor outcome of the disease (p=0.019) was detected. The results indicate that evaluation of changes in the expression of EGFR and HER-2 in tumors is essential for individual prediction of the disease course and development of new approaches to the treatment of these tumors, including target therapy aimed at these tyrosine kinase receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 8, pp. 213-217, August, 2009
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Delektorskaya, V.V., Chemeris, G.Y., Kononets, P.V. et al. Clinical Significance of Hyperexpression of Epidermal Growth Factor Receptors (EGFR and HER-2) in Esophageal Squamous Cell Carcinoma. Bull Exp Biol Med 148, 241 (2009). https://doi.org/10.1007/s10517-009-0659-z
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DOI: https://doi.org/10.1007/s10517-009-0659-z