Recombinant heat shock protein of mycobacterial origin with a molecular weight 70 kDa in concentration 0.1 μg/ml in vitro activates cytotoxic activity of mononuclear lymphocytes from peripheral blood of healthy donors against K-562 human erythroblastic leukemia cells sensitive to natural killers. In other concentrations (1.0 μg/ml and 10 μg/ml) this heat shock protein did not signifi cantly affect functional activity of mononuclear leukocytes. Expression of CD4, CD25, CD16 and CD56 on membrane of mononuclear leukocytes was also studied.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 7, pp. 76-79, July, 2009
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Vorobiev, D.S., Kiselevskii, M.V., Chikileva, I.O. et al. Effect of Recombinant Heat Shock Protein 70 of Mycobacterial Origin on Cytotoxic Activity and Immunophenotype of Human Peripheral Blood Mononuclear Leukocytes. Bull Exp Biol Med 148, 64–67 (2009). https://doi.org/10.1007/s10517-009-0622-z
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DOI: https://doi.org/10.1007/s10517-009-0622-z