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Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of dalargin and its analogue [Dala]2-leu-enkephalin on the gastric mucosa in indomethacin-receiving animals. Indomethacin treatment was followed by severe injury to the gastric mucosa, decrease in proliferative activity of the epithelium, and stimulation of free-radical processes in gastric tissues. Dalargin significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells, and reduced the degree of oxidative stress. Administration of [Dala]2-leu-enkephalin did not improve the state of the gastric mucosa.

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Authors and Affiliations

  1. Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia

    E. Yu. Zhivotova, M. Yu. Fleishman, E. N. Sazonova & S. S. Timoshin

  2. Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Khabarovsk, Russia

    O. A. Lebed’ko

Authors
  1. E. Yu. Zhivotova
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  2. M. Yu. Fleishman
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  3. E. N. Sazonova
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  4. O. A. Lebed’ko
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  5. S. S. Timoshin
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Corresponding author

Correspondence to S. S. Timoshin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 4, pp. 422–425, April, 2009

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Zhivotova, E.Y., Fleishman, M.Y., Sazonova, E.N. et al. Gastroprotective Effect of Dalargin in Gastropathy due to Treatment with Nonsteroid Antiinflammatory Drugs. Bull Exp Biol Med 147, 441–443 (2009). https://doi.org/10.1007/s10517-009-0518-y

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  • DOI: https://doi.org/10.1007/s10517-009-0518-y

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