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Oxidative Modification of Fibrinogen Inhibits Its Transformation into Fibrin under the Effect of Thrombin

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Bulletin of Experimental Biology and Medicine Aims and scope

Changes in the capacity of fibrinogen subjected to oxidative modification to transform into fibrin under the effect of thrombin and to form a fibrin clot were studied. The effects of oxidized fibrinogen preparations on the clot formation by citrate-treated donor plasma were evaluated by the thrombin time test. Oxidation impaired the capacity of isolated fibrinogen to form a fibrin clot under the effect of thrombin. Addition of oxidized fibrinogen solutions to donor plasma led to prolongation of the plasma clotting time. Maximum addition (33% volume) of oxidized fibrinogen led to a 10-26% prolongation of clotting time in comparison with addition of the same volume of the same solution without fibrinogen.

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Authors and Affiliations

  1. Laboratory of Biophysical Bases of Pathology, Institute of Physico-Chemical Medicine, Federal Agency for Public Health and Social Development, Moscow, Russia

    O. A. Azizova, A. P. Piryazev, A. V. Aseychev & A. G. Shvachko

Authors
  1. O. A. Azizova
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  2. A. P. Piryazev
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  3. A. V. Aseychev
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  4. A. G. Shvachko
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Corresponding author

Correspondence to O. A. Azizova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 160-163, February, 2009

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Azizova, O.A., Piryazev, A.P., Aseychev, A.V. et al. Oxidative Modification of Fibrinogen Inhibits Its Transformation into Fibrin under the Effect of Thrombin. Bull Exp Biol Med 147, 201–203 (2009). https://doi.org/10.1007/s10517-009-0474-6

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  • DOI: https://doi.org/10.1007/s10517-009-0474-6

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