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In vitro comparison of immunological properties of cultured human mesenchymal cells from various sources

  • Microbiology and Immunology
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Abstract

Cell-mediated cytotoxicity was studied in vitro during the interaction of bone marrow mesenchymal stem cells, fibroblast-like cells from newborn umbilical cord, and skin fibroblasts of an adult donor with peripheral blood mononuclear cells. Independently on the origin, mesenchymal cells were not lysed with allogeneic natural killer cells and cytotoxic lymphocytes. Mixed cultures of mesenchymal cells had no cytotoxic effect on peripheral blood mononuclear cells and did not activate proliferation of T and B lymphocytes, natural killer cells, and CD14+ lymphocytes. In vitro experiments showed that mesenchymal cells of different origin and allogeneic immunocompetent cells are tolerant to each other.

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Authors and Affiliations

  1. Russian State Medical University, Moscow, Russia

    Yu. G. Suzdaltseva, V. V. Burunova & K. N. Yarygin

  2. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia

    I. V. Vakhrushev, I. B. Cheglakov & K. N. Yarygin

Authors
  1. Yu. G. Suzdaltseva
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  2. V. V. Burunova
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  3. I. V. Vakhrushev
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  4. I. B. Cheglakov
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  5. K. N. Yarygin
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Corresponding author

Correspondence to Yu. G. Suzdaltseva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 188–191, February, 2008

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Suzdaltseva, Y.G., Burunova, V.V., Vakhrushev, I.V. et al. In vitro comparison of immunological properties of cultured human mesenchymal cells from various sources. Bull Exp Biol Med 145, 228–231 (2008). https://doi.org/10.1007/s10517-008-0057-y

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  • DOI: https://doi.org/10.1007/s10517-008-0057-y

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