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Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet

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Abstract

Serum concentration of L-carnitine, the mean thickness of the skeletal muscle fiber, and exercise performance in the forced swimming test decreased in rats receiving a carnitine-deficient diet. Treatment with L-carnitine compensated for carnitine deficiency, while racemate and D-stereoisomer did not increase its level. L-Carnitine, but not racemate and D-stereoisomer, promoted recovery of the skeletal muscle fiber thickness and exercise performance of rats.

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Authors and Affiliations

  1. Institute of Pharmacology, Volgograd State Medical University, Russia

    A. A. Spasov, I. N. Iezhitsa, M. S. Kravchenko, V. B. Pisarev & G. L. Snigur

Authors
  1. A. A. Spasov
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  2. I. N. Iezhitsa
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  3. M. S. Kravchenko
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  4. V. B. Pisarev
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  5. G. L. Snigur
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Correspondence to A. A. Spasov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 441–443, October, 2006

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Spasov, A.A., Iezhitsa, I.N., Kravchenko, M.S. et al. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. Bull Exp Biol Med 142, 458–460 (2006). https://doi.org/10.1007/s10517-006-0391-x

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  • DOI: https://doi.org/10.1007/s10517-006-0391-x

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