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Generation of reactive oxygen species by umbilical blood cells and immune status of newborns at risk of infectious inflammatory diseases

  • Immunology and Microbiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We carried out a comparative clinical and immunological examination of newborns whose mothers were at risk of infectious inflammatory diseases. Umbilical blood cell phenotype was evaluated by flow cytofluorometry. ROS level was evaluated by chemiluminescence intensity. Spontaneous production of ROS and phagocytic activity of cells in the whole umbilical blood was reduced in newborns born after complicated pregnancy. Low immunoregulatory index indicating changed CD4+/CD8+ ratio and low percentage of natural killer cells were observed in children with manifestations of bacterial infection. ROS production by isolated granulocytes and the effects of PI3K and p38 MAPK (kinases involved in the regulation of activity of NADPH oxidase responsible for the production of ROS) in the risk group infants differed from the corresponding parameters in the control group. The results indicate shifts in the phagocytosis system, immune status, and the receptor-conjugated regulatory systems of ROS generation by granulocytes in newborns at risk of infectious inflammatory diseases.

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References

  1. M. V. Degtyareva, N. N. Volodin, K. K. Bakhtikyan, et al., Med. Immunol., 2, No. 1, 69–76 (2000).

    Google Scholar 

  2. V. G. Safronova, N. K. Matveeva, V. N. Mal’tseva, et al., Byull. Eksp. Biol. Med., 140, No. 8, 173–176 (2005).

    Google Scholar 

  3. K. Q. Chen, P. Iribarren, W. H. Gong, et al., Cell. Mol. Immunol., 2, 241–252 (2005).

    PubMed  CAS  Google Scholar 

  4. U. H. Chudgar, G. W. Thurman, and D. R. Ambruso, Pediatr. Blood Cancer, 45, 311–317 (2005).

    Article  PubMed  Google Scholar 

  5. A. Davoren, K. Saving, J. G. McFarland, et al., Transfusion, 44, 1041–1046 (2004).

    Article  PubMed  CAS  Google Scholar 

  6. S. K. Kim, S. E. Keeney, S. K. Alpard, et al., Pediatr. Res., 53, 132–136 (2003).

    Article  PubMed  CAS  Google Scholar 

  7. H. Komatsu, K. Tsukimori, K. Hata, et al., Early Human Develop., 65, 11–19 (2001).

    Article  CAS  Google Scholar 

  8. O. Levy, K. A. Zarember, R. M. Roy, et al., J. Immunol., 173, 4627–4634 (2004).

    PubMed  CAS  Google Scholar 

  9. D. Luo, K. O. Schowengerdt, J. J. Stegner, et al., Pediatr. Res., 53, 859–864 (2003).

    Article  PubMed  CAS  Google Scholar 

  10. T. Mikami, M. Eguchi, H. Kurosawa, et al. Med. Electron. Microsc., 35, 96–101 (2002).

    Article  PubMed  Google Scholar 

  11. M. Nybo, O. Sorensen, R. Leslie, et al., Arch. Dis. Child. Fetal Neonatal Ed., 78, F129–F132 (1998).

    Article  PubMed  CAS  Google Scholar 

  12. L. Pollak, T. Hanoch, M. J. Rabey, et al., Neurol. Sci., 26, 324–329 (2005).

    Article  PubMed  CAS  Google Scholar 

  13. F. R. Sheppard, M. R. Kelher, E. E. Moore, et al., J. Leukoc. Biol., 78, 1025–1042 (2005).

    Article  PubMed  CAS  Google Scholar 

  14. L. Stephens, C. Ellson, and P. Hawkins, Curr. Opin. Cell. Biol., 14, 203–213 (2002).

    Article  PubMed  CAS  Google Scholar 

  15. J. S. Wang, H. Chen, and Q. R. Zhu, World J. Gastroenterol., 11, 3582–3585 (2005).

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia

    V. G. Safronova, V. N. Mal’tseva & N. V. Avkhacheva

  2. Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow

    N. K. Matveeva, O. E. Bondar’, I. N. Paskhina, L. V. Van’ko, L. P. Ponomaryova & G. T. Sukhikh

Authors
  1. V. G. Safronova
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  2. N. K. Matveeva
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  3. V. N. Mal’tseva
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  4. O. E. Bondar’
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  5. N. V. Avkhacheva
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  6. I. N. Paskhina
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  7. L. V. Van’ko
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  8. L. P. Ponomaryova
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  9. G. T. Sukhikh
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Corresponding author

Correspondence to V. G. Safronova.

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Translated From Byulleten’ Eksperimental’noi Biologii I Meditsiny, Vol. 142, No. 9, Pp. 304–308, September, 2006

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Safronova, V.G., Matveeva, N.K., Mal’tseva, V.N. et al. Generation of reactive oxygen species by umbilical blood cells and immune status of newborns at risk of infectious inflammatory diseases. Bull Exp Biol Med 142, 333–337 (2006). https://doi.org/10.1007/s10517-006-0359-x

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  • DOI: https://doi.org/10.1007/s10517-006-0359-x

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