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Overexpression of prolactin receptors during intrahepatic transplantation of RS1 rat cholangiocellular carcinoma cells

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Abstract

Immunohistochemical study showed that expression of prolactin receptors in intrahepatically transplanted cells of RS1 cholangiocellular carcinoma 2-fold exceeds that in cholangiocytes of intact rats. The number of prolactin receptors significantly increased in tumor cell nuclei of male and female animals. The RS1 transplant induced overexpression of prolactin receptors in hepatocytes and increased their number in nuclei of these cells.

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Authors and Affiliations

  1. Laboratory of Endocrinology, M. V. Lomonosov Moscow State University, Russia

    T. Yu. Ostroukhova, A. V. Kulikov & O. V. Smirnova

  2. Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    A. A. Rozenkrants

  3. Laboratory of Molecular Genetics of Intracellular Transport, Institute of Gene Biology, Russian Academy of Sciences, Moscow

    A. A. Rozenkrants

Authors
  1. T. Yu. Ostroukhova
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  2. A. V. Kulikov
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  3. A. A. Rozenkrants
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  4. O. V. Smirnova
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Corresponding author

Correspondence to T. Yu. Ostroukhova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 3, pp. 341–344, March, 2006

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Ostroukhova, T.Y., Kulikov, A.V., Rozenkrants, A.A. et al. Overexpression of prolactin receptors during intrahepatic transplantation of RS1 rat cholangiocellular carcinoma cells. Bull Exp Biol Med 141, 364–367 (2006). https://doi.org/10.1007/s10517-006-0172-6

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  • DOI: https://doi.org/10.1007/s10517-006-0172-6

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