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Mechanisms of the Effects of Granulocytic CSF on Tissue Reparation during Chronic CCl4-Induced Damage to the Liver

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Hepatoprotective effects of granulocytic CSF were studied using experimental model of CCl4-induced hepatitis. It was found that treatment with granulocytic CSF increased the content of stromal precursors and mesenchymal stem cells in the bone marrow and peripheral blood with subsequent increase in the number of hepatic precursor cells in the liver. These findings attest to mobilization of progenitor mesenchymal cells and their migration into damages liver tissue, which accelerates its regeneration related to changes in the parenchyma, but not connective tissue development.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, Russia

    N. V. Sotnikova, L. A. Stavrova, L. A. Gur'antseva, T. Yu. Khrichkova, T. I. Fomina, N. V. Vetoshkina, T. Yu. Dubskaya, S. A. Sergeeva, O. I. Epshtein, L. A. Ermolaeva, A. M. Dygai & E. D. Gol'dberg

  2. Materia-Medika Holding Research-and Production Company, Russia

    N. V. Sotnikova, L. A. Stavrova, L. A. Gur'antseva, T. Yu. Khrichkova, T. I. Fomina, N. V. Vetoshkina, T. Yu. Dubskaya, S. A. Sergeeva, O. I. Epshtein, L. A. Ermolaeva, A. M. Dygai & E. D. Gol'dberg

Authors
  1. N. V. Sotnikova
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  2. L. A. Stavrova
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  3. L. A. Gur'antseva
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  4. T. Yu. Khrichkova
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  5. T. I. Fomina
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  6. N. V. Vetoshkina
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  7. T. Yu. Dubskaya
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  8. S. A. Sergeeva
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  9. O. I. Epshtein
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  10. L. A. Ermolaeva
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  11. A. M. Dygai
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  12. E. D. Gol'dberg
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Additional information

__________

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 243–246, November, 2005

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Sotnikova, N.V., Stavrova, L.A., Gur'antseva, L.A. et al. Mechanisms of the Effects of Granulocytic CSF on Tissue Reparation during Chronic CCl4-Induced Damage to the Liver. Bull Exp Biol Med 140, 644–647 (2005). https://doi.org/10.1007/s10517-006-0044-0

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  • DOI: https://doi.org/10.1007/s10517-006-0044-0

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