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Role of Thy 1,2+ Cells in the Regulation of Hemopoiesis during Experimental Neuroses

  • General Pathology and Pathophysiology
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Abstract

We studied the direct and stromal cell-mediated effects of bone marrow Thy 1,2+ cells on the growth of granulocyte-macrophage and erythroid colonies from the bone marrow of CBA/CaLac mice with experimental neuroses (conflict situation and paradoxical sleep deprivation). Proliferation and differentiation of hemopoietic precursors during neuroses are controlled by regulatory T cells. In conflict situation Thy 1,2+ cells stimulate the growth of hemopoietic precursors, which is associated with their direct effect and interaction with adherent cells of the hemopoiesis-inducing microenvironment. The interaction of Thy 1,2+ cells with adherent bone marrow cells during paradoxical sleep deprivation stimulates the formation of only granulocyte-macrophage colonies.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Russia

    E. G. Skurikhin, O. V. Pershina, N. I. Suslov, A. M. Dygai & E. D. Gol’dberg

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  1. E. G. Skurikhin
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  2. O. V. Pershina
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  3. N. I. Suslov
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  4. A. M. Dygai
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  5. E. D. Gol’dberg
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Correspondence to E. D. Gol’dberg.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 6, pp. 608–612, June, 2005

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Skurikhin, E.G., Pershina, O.V., Suslov, N.I. et al. Role of Thy 1,2+ Cells in the Regulation of Hemopoiesis during Experimental Neuroses. Bull Exp Biol Med 139, 643–646 (2005). https://doi.org/10.1007/s10517-005-0366-3

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  • DOI: https://doi.org/10.1007/s10517-005-0366-3

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