Abstract
In Wistar and August rats characterized by different resistance to acute emotional stress we compared the resistance to neurodegenerative brain damage (model of Alzheimer’s disease) produced by administration of a neurotoxic peptide fragment (25–35) β-amyloid into the brain. August rats were more resistant to acute stress and development of neurodegenerative disorders compared to Wistar rats. This conclusion was derived from studying animal behavior in conditioned passive avoidance task and open-field test that characterize cognitive function of the brain. Administration of β-amyloid modulated the behavior of Wistar rats, which reflected the impairment of memory and orientation and exploratory activity in these animals. These disturbances in Wistar rats were accompanied by activation of lipid peroxidation in the hippocampus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
L. M. Belkina, V. L. Lakomkin, A. G. Zhukova, et al., Byull. Eksp. Biol. Med., 138, No.9, 250–253 (2004).
L. M. Belkina, V. A. Saltykova, and M. G. Pshennikova, Ibid., 131, No.6, 624–628 (2001).
N. A. Bondarenko, I. I. Miroshnichenko, V. S. Kudrin, and K. S. Raevskii, Ibid., 126, No.8, 168–170 (1988).
M. G. Pshennikova, Usp. Fiziol. Nauk, 34, No.3, 55–67 (2003).
M. G. Pshennikova, N. A. Bondarenko, M. V. Shimkovich, et al., Byull. Eksp. Biol. Med., 128, No.12, 638–641 (1999).
M. G. Pshennikova, L. Yu. Golubeva, B. A. Kuznetsova, et al., Ibid., 122, No.8, 156–159 (1996).
M. G. Pshennikova, E. V. Popkova, N. A. Bondarenko, et al., Ros. Fiziol. Zh., 88, No.4, 485–495 (2002).
V. I. Sergienko and I. B. Bondareva, Mathematical Statistics in Clinical Studies [in Russian], Moscow (2001).
D. A. Butterfield, B. Howard, S. Yatin, et al., Life Sci., 65, 1883–1892 (1999).
T. Harkany, S. O’Mahony, J. P. Kelly, et al., Behav. Brain Res., 90, No.2, 133–145 (1998).
A. Law, S. Gauthier, and R. Quirion, Brain Res. Rev., 35, No.1, 73–96 (2001).
R. Popa, F. Schneider, G. Mihalas, et al., Arch. Gerontol. Geriatr., Suppl. 4, 197–206 (1994).
Stress and the Aging Brain. Integrative Mechanisms, Eds. G. Nappi et al., New York (1990).
E. A. van der Zee, B. R. Dauma, B. Bohus, and P. G. Luiten, Cereb. Cortex, 4, No.4, 376–390 (1994).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 5, pp. 491–494, May, 2005
Rights and permissions
About this article
Cite this article
Pshennikova, M.G., Popkova, E.V., Khomenko, I.P. et al. Resistance to Neurodegenerative Brain Damage in August and Wistar Rats. Bull Exp Biol Med 139, 540–542 (2005). https://doi.org/10.1007/s10517-005-0340-0
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0340-0