Abstract
Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 451–455, April, 2005
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Simonova, V.S., Samusenko, A.V., Filippova, N.A. et al. Olivomycin Induces Tumor Cell Apoptosis and Suppresses p53-Induced Transcription. Bull Exp Biol Med 139, 455–459 (2005). https://doi.org/10.1007/s10517-005-0321-3
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DOI: https://doi.org/10.1007/s10517-005-0321-3