Abstract
Female patient with extensive skin burn (I-II-IIIAB skin burn, total area 40%, area of IIIB degree 30%) was treated using transplantation of allogenic fibroblast-like bone marrow mesenchymal stem cells onto the surface of deep thermal burn. The study of wound healing dynamics after transplantation of allogenic fibroblast-like mesenchymal stem cells confirmed high tempo of wound regeneration in the presence of active neoangiogenesis. Due to this, autodermoplasty of burn wounds could be carried out with good results as early as on day 4 after transplantation of fibroblast-like mesenchymal stem cells; this led to more rapid healing of donor zones and accelerated rehabilitation of the patient.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
E. G. Kolokol’chikova, L. I. Budkevich, A. E. Bobrovnikov, et al., Byull. Eksp. Biol. Med., 131, No.1, 107–111 (2001).
E. N. Matchin, V. P. Potapov, V. A. Ogol’tsova, and Yu. N. Kuz’ko, New Methods for Treatment of Burns Using Cultured Skin Cells [in Russian], Proceedings of II International Workshop, May 1998, Saratov (1998), P. 25.
B. A. Paramonov, T. D. Smirnova, L. V. Kukhareva, et al., Combustiology on the Brink of Two Centuries [in Russian], October 9–12, 2000, Moscow (2000), P. 164.
M. F. Rasulov, A. M. Khadzhibaev, and M. D. Urazmetova, Med. Zh. Uzbekistana, Nos. 5–6, 87–88 (2001).
G. Z. Saidgalin, P. V. Salistyi, O. V. Panova, et al., Combustiology on the Brink of Two Centuries [in Russian], October 9–12, 2000, Moscow (2000), P. 166.
D. S. Sarkisov, A. A. Alekseev, E. V. Glushchenko, et al., Vestn. Rossiisk. Akad. Med. Nauk, No. 6, 6–11 (1996).
V. P. Tumanov, E. V. Glushchenko, S. S. Morozov, and D. S. Sarkisov, Byull. Eksp. Biol. Med., 109, No.4, 400–403 (1990).
V. P. Tumanov, A. A. Pal’tsin, and D. S. Sarkisov, Acta Chir. Plast., 31, 14–20 (1989).
V. D. Fedorov, D. S. Sarkisov, A. A. Alekseev, et al., Ann. Khir., No. 4, 16 (1996).
V. I. Shumakov, N. A. Onishchenko, M. F. Rasulov, et al., Vestn. Khir., 162, No.4, 38–41 (2003).
V. I. Shumakov, N. A. Onishchenko, M. F. Rasulov, et al., Byull. Eksp. Biol. Med., 136, No.8, 220–223 (2003).
V. I. Shumakov, M. F. Rasulov, M. E. Krasheninnikov, et al., Vestn. Transplantol. Iskusstv. Organov, No. 4, 7–11 (2002).
T. Asahara, T. Murohara, and A. Sullivan, Science, 275, 964–967 (1997).
N. W. DeLapp and D. K. Dieckman, J. Invest. Dermat., 94, No.6, 777–780 (1990).
Z. Dedovic, I. Koupilovia, and I. Suchanek, Ann. Burns Fire Disasters, 11, No.1, 37–40 (1998).
R. Gruber, C. Mayer, W. Schulz, et al., Cytokine, 12, No.11, 1630–1638 (2000).
M. K. Majumdar, V. Banks, D. P. Peluso, et al., J. Cell Physiol., 185, No.1, 98–106 (2000).
M. F. Pittenger, A. M. Mackay, S. C. Beck, et al., Science, 284, 143–147 (1999).
B. Seshi, S. Kumar, and D. Sellers, Blood Cells Mol. Dis., 26, No.3, 234–246 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Kletochnye Tekhnologii v Biologii i Meditsine, Vol. 1, No. 1, pp. 42–46, January, 2005
Rights and permissions
About this article
Cite this article
Rasulov, M.F., Vasil’chenkov, A.V., Onishchenko, N.A. et al. First experience in the use of bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns. Bull Exp Biol Med 139, 141–144 (2005). https://doi.org/10.1007/s10517-005-0232-3
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0232-3