Skip to main content

Advertisement

SpringerLink
Log in

Transplantation of cultured human neural stem cells in rabbits with experimental laser-induced damage to the retina

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Cultured neural stem/progenitor cells from human fetal brain were transplanted into the retrobulbar and suprachoroid space in rabbits with laser-induced damage to the retina. Transplanted cells survived, retained multipotent activity, migrated into the zone of injury, and stimulated reparation and regeneration in the traumatized retina.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. M. A. Aleksandrova, R. A. Poltavtseva, M. V. Marey, et al., Byull. Eksp. Biol. Med., 132, No. 10, 455–458 (2001).

    Google Scholar 

  2. N. F. Gamaleya, Lasers in Experiment and Clinics [in Russian], Moscow (1972), pp. 101–108.

  3. O. V. Podgornyi, I. V. Kheifets, M. A. Aleksandrova, et al., Byull. Eksp. Biol. Med., 137, No. 4, 394–398 (2004).

    Google Scholar 

  4. F. H. Gage, Science, 287, 1433–1438 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. R. Kubota, J. N. Horoc, A. Moshiri, et al., Dev. Brain Res., 134, 31–41 (2002).

    Google Scholar 

  6. Y. Kurimoto, H. Shibuki, Y. Kaneko, et al., Neurosci. Lett., 306, Nos. 1–2, 57–60 (2001).

    Google Scholar 

  7. P. Lu, L. L. Jones, E. Y. Snyder, and M. H. Tuszynski, Exp. Neurol., 181, No. 2, 115–129 (2003).

    Google Scholar 

  8. E. J. Mayer, E. H. Hughes, D. A. Carter, and A. D. Dick, Br. J. Ophthalmol., 87, No. 9, 1154–1158 (2003).

    Google Scholar 

  9. A. Nishida, M. Takahashi, H. Tamihara, et al., Invest. Ophthalmol. Vis. Sci., 41, 4268–4278 (2000).

    Google Scholar 

  10. R. A. Poltavtseva, M. V. Marey, M. A. Aleksandrova, et al., Dev. Brain Res., 134, 149–154 (2002).

    Google Scholar 

  11. W. Radner, S. Sadda, M. S. Hymayun, et al., Invest. Ophthalmol. Vis. Sci., 43, No. 9, 3053–3058 (2002).

    Google Scholar 

  12. U. Schraermeyer, G. Thumann, T. Luther, et al., Cell Transplant., 10, 673–680 (2001).

    Google Scholar 

  13. V. Tropepe, B. Coles, B. J. Chiasson, et al., Science, 287, 2032–2036 (2000).

    Google Scholar 

  14. S. J. Van Hoffelen, M. J. Young, M. A. Shatos, et al., Invest. Ophthalmol. Vis. Sci., 44, 426–434 (2003).

    Google Scholar 

  15. M. J. Young, J. Ray, S. J. Whiteley, et al., Mol. Cell Neurosci., 16, 197–205 (2000).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ghelmgolts Moscow Research Institute of Eye Diseases, Russian Ministry of Health, Russia

    N. V. Pak, E. V. Chentsova & A. N. Ivanov

  2. N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Russia

    O. V. Podgornyi, M. A. Aleksandrova & R. A. Poltavtseva

  3. Institute of Gene Biology, Russian Academy of Sciences, Russia

    O. N. Golubeva

  4. Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow

    M. V. Marey & G. T. Sukhikh

Authors
  1. N. V. Pak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. V. Podgornyi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Aleksandrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. V. Chentsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. N. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. N. Golubeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. A. Poltavtseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. V. Marey
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. G. T. Sukhikh
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 11, pp. 592–596, November, 2004

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pak, N.V., Podgornyi, O.V., Aleksandrova, M.A. et al. Transplantation of cultured human neural stem cells in rabbits with experimental laser-induced damage to the retina. Bull Exp Biol Med 138, 525–528 (2004). https://doi.org/10.1007/s10517-005-0087-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-005-0087-7

Key Words

Search

Navigation