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Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis

  • Genetics
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Abstract

Metabolites of Trichinella spiralis produced genotoxic and cytotoxic effects on somatic and generative cells of the host organism. They increased the number of single-chain breaks, alkaline-labile sites in nuclear DNA, and count of apoptotic cells in the bone marrow and testes of infected mice. These effects depended on the stage of parasite development in the host organism and became more pronounced with increasing invasion intensity.

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Authors and Affiliations

  1. Department of Medical Biology and General Genetics, Vitebsk State Medical University, Russia

    Vl. Ya. Bekish

  2. Laboratory for Pharmacology of Mutagenesis, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    A. D. Durnev

Authors
  1. Vl. Ya. Bekish
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  2. A. D. Durnev
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Correspondence to Vl. Ya. Bekish.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 9, pp. 320–323, September, 2004

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Bekish, V.Y., Durnev, A.D. Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis. Bull Exp Biol Med 138, 284–287 (2004). https://doi.org/10.1007/s10517-005-0022-y

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  • DOI: https://doi.org/10.1007/s10517-005-0022-y

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