149Tb is currently considered to be a promising α-emitting isotope radioimmunotherapy. It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of Eu2O3 with 4He with energy 63 MeV. After irradiation, radiochemical separation of terbium radioisotopes was performed in a time not exceeding the half-life of 149Tb (4.12 h). It was based on reductive co-precipitation of europium and extraction-chromatographic purification. The obtained product, including 149Tb and the associated terbium radioisotopes, were analyzed by means of alpha- and gamma-spectrometry. It was concluded that the combination and sequence of approaches used in this work allow rapid production of short-lived 149Tb and the use of the technological route implemented in this work in practice.
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Translated from Atomnaya Énergiya, Vol. 129, No. 6, pp. 326–328, December, 2020.
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Aliev, R.A., Zagryadskiy, V.A., Latushkin, S.T. et al. Production of a Short-Lived Therapeutic α-Emitter 149Tb by Irradiation of Europium by 63 MeV α-Particles. At Energy 129, 337–340 (2021). https://doi.org/10.1007/s10512-021-00758-z
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DOI: https://doi.org/10.1007/s10512-021-00758-z