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Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers

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A Correction to this article was published on 12 November 2018

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Abstract

Photodynamic therapy (PDT) is a procedure used in cancer therapy that has been shown to be useful for certain indications. Considerable evidence suggests that PDT might be superior to conventional modalities for some indications. In this report, we examine the relationship between PDT responsiveness and autophagy, which can exert a cytoprotective effect. Autophagy is an essential physiological process that maintains cellular homeostasis by degrading dysfunctional or impaired cellular components and organelles via a lysosome-based pathway. Autophagy, which includes macroautophagy and microautophagy, can be a factor that decreases or abolishes responses to various therapeutic protocols. We systematically discuss the mechanisms underlying cell-fate decisions elicited by PDT; analyse the principles of PDT-induced autophagy, macroautophagy and microautophagy; and present evidence to support the notion that autophagy is a critical mechanism in resistance to PDT. A combined strategy involving autophagy inhibitors may be able to further enhance PDT efficacy. Finally, we provide suggestions for future studies, note where our understanding of the relevant molecular regulators is deficient, and discuss the correlations among PDT-induced resistance and autophagy, especially microautophagy.

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Change history

  • 12 November 2018

    The below funding information was not submitted and hence not included in the original publication. The funding information is given below.

  • 12 November 2018

    The below funding information was not submitted and hence not included in the original publication. The funding information is given below.

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  1. Xian Duan and Bo Chen have contributed equally to the work.

Authors and Affiliations

  1. Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China

    Xian Duan & Lin Zhou

  2. Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China

    Bo Chen, Zhulin Yang, Yu Wen, Xiongying Miao, Qinglong Li, Li Xiong & Jun He

  3. Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, China

    Yanan Cui & Chenkai Wu

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  1. Xian Duan
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Duan, X., Chen, B., Cui, Y. et al. Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers. Apoptosis 23, 587–606 (2018). https://doi.org/10.1007/s10495-018-1489-0

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