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Zipper interacting protein kinase (ZIPK): function and signaling

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Abstract

Zipper interacting protein kinase (ZIPK), also known as death associated protein kinase 3, is a serine/threonine kinase that mediates variety of cell functions. The major biologic function of ZIPK is considered to be the regulation of apoptosis and smooth muscle contraction. Recently, several other functions of ZIPK have been gradually clarified. In this review article, we summarized the recent findings on ZIPK function and ZIPK-related cell signaling. We propose that ZIPK is a potential future target for the development of pharmaceutical therapy for cancer as well as cardiovascular diseases.

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Abbreviations

ZIPK:

Zipper interacting protein kinase

DAPK:

Death associated protein kinase

ATF:

Activating transcription factor

CaM:

Calmodulin

DRAK:

DAPK-related apoptosis-inducing protein kinase

STAT:

Signal transducer and activator of transcription

MYPT:

Myosin phosphatase targeting subunit

PAR:

Prostate apoptosis response

LC:

Light chain

MLC:

Myosin LC

TNF:

Tumor necrosis factor

VCAM:

Vascular cell adhesion molecule

ROS:

Reactive oxygen species

SMCs:

Smooth muscle cells

SHR:

Spontaneously hypertensive rats

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Acknowledgment

This study was supported in part by a Grant for Scientific Research from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada, Aomori, 034-8628, Japan

    Tatsuya Usui, Muneyoshi Okada & Hideyuki Yamawaki

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  1. Tatsuya Usui
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  2. Muneyoshi Okada
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  3. Hideyuki Yamawaki
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Correspondence to Hideyuki Yamawaki.

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Usui, T., Okada, M. & Yamawaki, H. Zipper interacting protein kinase (ZIPK): function and signaling. Apoptosis 19, 387–391 (2014). https://doi.org/10.1007/s10495-013-0934-3

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  • DOI: https://doi.org/10.1007/s10495-013-0934-3

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