Skip to main content
SpringerLink
Log in

p53 and Retinoblastoma protein (pRb): A complex network of interactions

  • Published:
Apoptosis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Lipinski MM, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene 1999; 18: 7873–7882.

    Article  PubMed  CAS  Google Scholar 

  2. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323–330.

    Article  PubMed  CAS  Google Scholar 

  3. Zheng L, Lee WH. The retinoblastoma gene: A prototypic and multifunctional tumor suppressor. Exp Cell Res 2001; 264: 2–18.

    Article  PubMed  CAS  Google Scholar 

  4. Harbour JW, Dean DC. Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2000; 2: E65–E67.

    Article  PubMed  CAS  Google Scholar 

  5. Macleod K. pRb and E2f-1 in mouse development and tumorigenesis. Curr Opin Genet Dev 1999; 9: 31–39.

    Article  PubMed  CAS  Google Scholar 

  6. Fogal V, Hsieh JK, Royer C, Zhong S, Lu X. Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315. Embo J 2005; 24: 2768–2782.

    Article  PubMed  CAS  Google Scholar 

  7. Hsieh JK, Yap D, O'Connor DJ, et al. Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol 2002; 22: 78–93.

    Article  PubMed  CAS  Google Scholar 

  8. Wu XW, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 1994; 91: 3602–3606.

    Article  PubMed  CAS  Google Scholar 

  9. Prives C. Signaling to p53: Breaking the MDM2-p53 circuit. Cell 1998; 95: 5–8.

    Article  PubMed  CAS  Google Scholar 

  10. Hershko T, Chaussepied M, Oren M, Ginsberg D. Novel link between E2F and p53: Proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ 2005; 12: 377–383.

    Article  PubMed  CAS  Google Scholar 

  11. Decary S, Decesse JT, Ogryzko V, et al. The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Mol Cell Biol 2002; 22: 7877–7888.

    Article  PubMed  CAS  Google Scholar 

  12. Lipinski MM, Macleod KF, Williams BO, et al. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. Embo J 2001; 20: 3402–3413.

    Article  PubMed  CAS  Google Scholar 

  13. Haupt Y, Rowan S, Oren M. p53-mediated apoptosis in HeLa cells can be overcome by excess pRb. Oncogene 1995; 10: 1562–1571.

    Google Scholar 

  14. Shinohara H, Zhou J, Yoshikawa K, et al. Retinoblastoma protein-initiated cellular growth arrest overcomes the ability of cotransfected wild-type p53 to induce apoptosis. Br J Cancer 2000; 83: 1039–1046.

    Article  PubMed  CAS  Google Scholar 

  15. Osifchin NE, Jiang D, Ohtani-Fujita N, et al. Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter. J Biol Chem 1994; 269: 6383–6389.

    PubMed  CAS  Google Scholar 

  16. Porrello A, Cerone MA, Coen S, et al. p53 regulates myogenesis by triggering the differentiation activity of pRb. J Cell Biol 2000; 151: 1295–1304.

    Article  PubMed  CAS  Google Scholar 

  17. Sionov RV, Haupt Y. The cellular response to p53: The decision between life and death. Oncogene 1999; 18: 6145–6157.

    Article  PubMed  CAS  Google Scholar 

  18. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 1994; 371: 72–74.

    Article  PubMed  CAS  Google Scholar 

  19. Symonds H, Krall L, Remington L, et al. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 1994; 78: 703–711.

    Article  PubMed  CAS  Google Scholar 

  20. Zhao X, Day ML. RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells. Urology 2001; 57: 860–865.

    Article  PubMed  CAS  Google Scholar 

  21. Bowen C, Birrer M, Gelmann EP. Retinoblastoma protein-mediated apoptosis after gamma-irradiation. J Biol Chem 2002; 277: 44969–44979.

    Article  PubMed  CAS  Google Scholar 

  22. Bowen C, Spiegel S, Gelmann EP. Radiation-induced apoptosis mediated by retinoblastoma protein. Cancer Res 1998; 58: 3275–3281.

    PubMed  CAS  Google Scholar 

  23. Day ML, Foster RG, Day KC, et al. Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway. J Biol Chem 1997; 272: 8125–8128.

    Article  PubMed  CAS  Google Scholar 

  24. Knudsen KE, Weber E, Arden KC, et al. The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: Inhibition of cell cycle progression and induction of cell death. Oncogene 1999; 18: 5239–5245.

    Article  PubMed  CAS  Google Scholar 

  25. Hsieh JK, Chan FS, O'Connor DJ, et al. RB regulates the stability and the apoptotic function of p53 via MDM2. Mol Cell 1999; 3: 181–193.

    Article  PubMed  CAS  Google Scholar 

  26. Bremner R, Du DC, Connolly-Wilson MJ, et al. Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma. Am J Hum Genet 1997; 61: 556–570.

    PubMed  CAS  Google Scholar 

  27. Lemaire C, Godefroy N, Costina-Parvu I, et al. Caspase-9 can antagonize p53-induced apoptosis by generating a p76Rb truncated form of Rb. Oncogene 2005; 24: 3297–3308.

    Article  PubMed  CAS  Google Scholar 

  28. Chen WD, Otterson GA, Lipkowitz S, et al. Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding. Oncogene 1997; 14: 1243–1248.

    Article  PubMed  CAS  Google Scholar 

  29. Boutillier AL, Trinh E, Loeffler JP. Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis. Oncogene 2000; 19: 2171–2178.

    Article  PubMed  CAS  Google Scholar 

  30. Janicke RU, Walker PA, Lin XY, Porter AG. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. Embo J 1996; 15: 6969–6978.

    PubMed  CAS  Google Scholar 

  31. Fattman CL, Delach SM, Dou QP, Johnson DE. Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. Oncogene 2001; 20: 2918–2926.

    Article  PubMed  CAS  Google Scholar 

  32. Chau BN, Borges HL, Chen TT, et al. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol 2002; 4: 757–765.

    Article  PubMed  CAS  Google Scholar 

  33. Gottlieb E, Oren M. p53 facilitates pRb cleavage in IL-3-deprived cells: Novel pro-apoptotic activity of p53. Embo J 1998; 17: 3587–3596.

    Article  PubMed  CAS  Google Scholar 

  34. Lozano G, Zambetti GP. Gankyrin: An intriguing name for a novel regulator of p53 and RB. Cancer Cell 2005; 8: 3–4.

    Article  PubMed  CAS  Google Scholar 

  35. Uchida C, Miwa S, Kitagawa K, et al. Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. Embo J 2005; 24: 160–169.

    Article  PubMed  CAS  Google Scholar 

  36. Stiewe T, Stanelle J, Theseling CC, et al. Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73. J Biol Chem 2003; 278: 14230–14236.

    Article  PubMed  CAS  Google Scholar 

  37. Liu H, Dibling B, Spike B, Dirlam A, Macleod K. New roles for the RB tumor suppressor protein. Curr Opin Genet Dev 2004; 14: 55–64.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Génétique et Biologie Cellulaire (CNRS UMR8159) and Laboratoire de Génétique Moléculaire et Physiologique (EPHE), Université de Versailles Saint-Quentin-en-Yvelines, 45 Avenue des Etats-Unis, 78035, Versailles Cedex, France

    N. Godefroy, C. Lemaire, B. Mignotte & J.-L. Vayssière

Authors
  1. N. Godefroy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Lemaire
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Mignotte
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J.-L. Vayssière
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J.-L. Vayssière.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Godefroy, N., Lemaire, C., Mignotte, B. et al. p53 and Retinoblastoma protein (pRb): A complex network of interactions. Apoptosis 11, 659–661 (2006). https://doi.org/10.1007/s10495-006-5543-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10495-006-5543-y

Keywords

Search

Navigation