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Personal Approach to Treatment Choices for HIV (PATCH): Randomized Controlled Trial of a Brief Motivational Enhancement Intervention to Improve Medication Adherence in Persons with HIV

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Abstract

This pilot randomized controlled trial evaluated the feasibility and efficacy of a brief motivational enhancement intervention to improve adherence to antiretroviral therapy in persons with HIV called Personal Approach to Treatment Choices for HIV (PATCH). We compared PATCH to an active control condition on self-reported adherence, clinical outcomes, and psychosocial outcomes. Participants were 34 individuals (61.8% male, Mage = 47.1) receiving HIV-related services who were suboptimally engaged in care. Participants completed baseline measures, participated in either PATCH or a stress reduction skills control intervention, and completed post-treatment and 3-month follow-up assessments. Results revealed no differences between conditions on adherence or clinical outcomes. At post-treatment, PATCH participants reported greater improvements in alcohol use, psychiatric symptoms, subjective mental functioning, and emotion-focused coping; improvements in subjective mental functioning were maintained at 3-months. Results suggest that motivational enhancement interventions can improve psychosocial outcomes for people with HIV. That some improvements were not maintained at follow-up suggests that effects wane over time and longer treatment may be indicated for lasting effects.

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Funding

This study was funded by NIMH 5R34MH092208 (Bennett & Himelhoch, co-PIs).

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Authors and Affiliations

  1. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA

    Jacob Scharer, Rachel Arnold, Deborah Medoff & Melanie E. Bennett

  2. Minds in Focus Psychological Services, Baltimore, MD, USA

    Rebecca Wald

  3. Mount Sinai Hospital, New York, NY, USA

    Jamie Nichols

  4. Department of Psychiatry, University of Kentucky College of Medicine, Lexington, KY, USA

    Seth Himelhoch

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  1. Jacob Scharer
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Correspondence to Melanie E. Bennett.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Scharer, J., Arnold, R., Wald, R. et al. Personal Approach to Treatment Choices for HIV (PATCH): Randomized Controlled Trial of a Brief Motivational Enhancement Intervention to Improve Medication Adherence in Persons with HIV. AIDS Behav 24, 1893–1902 (2020). https://doi.org/10.1007/s10461-019-02759-3

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  • DOI: https://doi.org/10.1007/s10461-019-02759-3

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