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High Prevalence of Anal Human Papillomavirus Infection and Associated Risky Behaviors in Men Infected with Human Immunodeficiency Virus in Taiwan

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Abstract

A cross-sectional study was conducted to investigate the prevalence, types, and risk factors associated with anal HPV infection among HIV-infected men in outpatient clinics at an AIDS designated hospital in Taiwan. Anal swabs were collect and PCR (polymerase chain reaction) was used to analyze the types of anal HPV infection. HPV DNA was detected in 74.2% of the 198 participants, including high-risk types (40.4%), low-risk types (18.2%) and multiple-types (6%). The most common types were HPV 16 (13.1%), 6 (10.4%), 11 (7.1%) and 18 (6.1%). The significant risk factor for being infected with any type or a high-risk type of HPV was having sexual partners (>3) in the preceding 6 months. Low-risk type of anal HPV infection was associated with a history of anal lesions. Our findings support the need for regular follow-up of all HIV/HPV coinfected patients and their partners to allow early detection of anal intraepithelial neoplasia.

Resumen

Un estudio transversal se llevó a cabo para investigar la prevalencia, tipos y factores de riesgo asociados con la infección anal por VPH en hombres infectados con VIH en clínicas para pacientes ambulatorios en un hospital de SIDA designado en Taiwán. Hisopados anales serecogen y PCR (reacción en cadena de la polimerasa) para analizar los tipos de infección anal por VPH. ADN del VPH se detectó en el 74,2% de los 198 participantes, entre los tipos de alto riesgo (40,4%), tipos de bajo riesgo (18,2%) y de varios tipos (6%). Los tipos más comunesfueron el VPH 16 (13,1%), 6 (10,4%), 11 (7,1%) y 18 (6,1%). El factor de riesgo significativo de ser infectado con cualquier tipo o un tipo de alto riesgo del VPH fue de parejas sexuales (>3) enlos seis meses anteriores. De bajo riesgo, el tipo de infección anal por VPH se asoció con un historial de lesiones anales. Nuestros hallazgos apoyan la necesidad de un seguimiento regularde todos los pacientes VIH/VPH coinfectados y sus socios para permitir la detección precoz de la neoplasia intraepitelial anal.

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References

  1. Dunne EF, Nielson CM, Stone KM, Markowitz LE, Giuliano AR. Prevalence of HPV infection among men: a systematic review of the literature. J Infect Dis. 2006;194(8):1044–57.

    Article  PubMed  Google Scholar 

  2. de la Fuente SG, Ludwig KA, Mantyh CR. Preoperative immune status determines anal condyloma recurrence after surgical excision. Dis Colon Rectum. 2003;46(3):367–73.

    Article  PubMed  Google Scholar 

  3. de Pokomandy A, Rouleau D, Ghattas G, Vezina S, Cote P, Macleod J, et al. Prevalence, clearance, and incidence of anal human papillomavirus infection in HIV-infected men: the HIPVIRG cohort study. J Infect Dis. 2009;199(7):965–73.

    Article  PubMed  Google Scholar 

  4. Sobhani I, Walker F, Roudot-Thoraval F, Abramowitz L, Johanet H, Henin D, et al. Anal carcinoma: incidence and effect of cumulative infections. AIDS. 2004;18(11):1561–9.

    Article  PubMed  Google Scholar 

  5. Piketty C, Darragh TM, Heard I, Da Costa M, Bruneval P, Kazatchkine MD, et al. High prevalence of anal squamous intraepithelial lesions in HIV-positive men despite the use of highly active antiretroviral therapy. Sex Transm Dis. 2004;31(2):96–9.

    Article  PubMed  Google Scholar 

  6. Vajdic CM, van Leeuwen MT. What types of cancers are associated with immune suppression in HIV? Lessons from solid organ transplant recipients. Curr Opin HIV AIDS. 2009;4(1):35–41.

    Article  PubMed  Google Scholar 

  7. Palefsky JM, Holly EA, Efirdc JT, Da Costa M, Jay N, Berry JM, et al. Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS. 2005;19(13):1407–14.

    Article  PubMed  Google Scholar 

  8. Palefsky JM, Holly EA, Ralston ML, Jay N. Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J Infect Dis. 1998;177(2):361–7.

    Article  PubMed  CAS  Google Scholar 

  9. Pierangeli A, Scagnolari C, Degener AM, Bucci M, Ciardi A, Riva E, et al. Type-specific human papillomavirus-DNA load in anal infection in HIV-positive men. AIDS. 2008;22(15):1929–35.

    Article  PubMed  CAS  Google Scholar 

  10. Vajdic CM, van Leeuwen MT, Jin F, Prestage G, Medley G, Hillman RJ, et al. Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men. Sex Transm Infect. 2009;85(5):330–5.

    Article  PubMed  CAS  Google Scholar 

  11. Nyitray A, Nielson CM, Harris RB, Flores R, Abrahamsen M, Dunne EF, et al. Prevalence of and risk factors for anal human papillomavirus infection in heterosexual men. J Infect Dis. 2008;197(12):1676–84.

    Article  PubMed  Google Scholar 

  12. Piketty C, Darragh TM, Da Costa M, Bruneval P, Heard I, Kazatchkine MD, et al. High prevalence of anal human papillomavirus infection and anal cancer precursors among HIV-infected persons in the absence of anal intercourse. Ann Intern Med. 2003;138(6):453–9.

    PubMed  Google Scholar 

  13. Chin-Hong PV, Vittinghoff E, Cranston RD, Buchbinder S, Cohen D, Colfax G, et al. Age-Specific prevalence of anal human papillomavirus infection in HIV-negative sexually active men who have sex with men: the EXPLORE study. J Infect Dis. 2004;190(12):2070–6.

    Article  PubMed  Google Scholar 

  14. Critchlow CW, Hawes SE, Kuypers JM, Goldbaum GM, Holmes KK, Surawicz CM, et al. Effect of HIV infection on the natural history of anal human papillomavirus infection. AIDS. 1998;12(10):1177–84.

    Article  PubMed  CAS  Google Scholar 

  15. Goldstone S, Palefsky JM, Giuliano AR, Moreira ED Jr, Aranda C, Jessen H, et al. Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. J Infect Dis. 2011;203(1):66–74.

    Article  PubMed  Google Scholar 

  16. Nielson CM, Harris RB, Nyitray AG, Dunne EF, Stone KM, Giuliano AR. Consistent condom use is associated with lower prevalence of human papillomavirus infection in men. J Infect Dis. 2010;202(3):445–51.

    Article  PubMed  Google Scholar 

  17. Drobacheff C, Dupont P, Mougin C, Bourezane Y, Challier B, Fantoli M, et al. Anal human papillomavirus DNA screening by hybrid capture II in human immunodeficiency virus-positive patients with or without anal intercourse. Eur J Dermatol. 2003;13(4):367–71.

    PubMed  CAS  Google Scholar 

  18. Canadas MP, Darwich L, Sirera G, Bofill M, Pinol M, Garcia-Cuyas F, et al. Human papillomavirus 16 integration and risk factors associated in anal samples of HIV-1 infected men. Sex Transm Dis. 2010;37(5):311–5.

    PubMed  Google Scholar 

  19. Jong E, van Gorp EC, Mulder JW, Tol A, Smits PH. Effect of HIV viral load, CD4 cell count and antiretroviral therapy on human papillomavirus prevalence in urine samples of HIV-infected men. Int J STD AIDS. 2009;20(4):262–4.

    Article  PubMed  CAS  Google Scholar 

  20. Moscicki AB, Durako SJ, Houser J, Ma Y, Murphy DA, Darragh TM, et al. Human papillomavirus infection and abnormal cytology of the anus in HIV-infected and uninfected adolescents. AIDS. 2003;17(3):311–20.

    Article  PubMed  Google Scholar 

  21. Anderson JS, Hoy J, Hillman R, Barnden M, Eu B, McKenzie A, et al. A randomized, placebo-controlled, dose-escalation study to determine the safety, tolerability, and immunogenicity of an HPV-16 therapeutic vaccine in HIV-positive participants with oncogenic HPV infection of the anus. J Acquir Immune Defic Syndr. 2009;52(3):371–81.

    Article  PubMed  Google Scholar 

  22. Wilkin T, Lee JY, Lensing SY, Stier EA, Goldstone SE, Berry JM, et al. Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected men. J Infect Dis. 2010;202(8):1246–53.

    Article  PubMed  Google Scholar 

  23. Neutens JJ, Rubinson L. Research techniques for the health sciences. 3rd ed. San Francisco: Benjamin Cummings; 2001.

    Google Scholar 

  24. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518–27.

    Article  PubMed  Google Scholar 

  25. Nielson CM, Harris RB, Flores R, Abrahamsen M, Papenfuss MR, Dunne EF, et al. Multiple-type human papillomavirus infection in male anogenital sites: prevalence and associated factors. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1077–83.

    Article  PubMed  Google Scholar 

  26. Poizot-Martin I, Henry M, Benhaim S, Obry-Roguet V, Figarella D, Tamalet C. High level of HPV 16 and 18 DNA load in anal swabs from male and female HIV-1 infected patients. J Clin Virol. 2009;44(4):314–7.

    Article  PubMed  CAS  Google Scholar 

  27. Chin-Hong PV, Vittinghoff E, Cranston RD, Browne L, Buchbinder S, Colfax G, et al. Age-related prevalence of anal cancer precursors in homosexual men: the EXPLORE study. J Natl Cancer Inst. 2005;97(12):896–905.

    Article  PubMed  Google Scholar 

  28. Sirera G, Videla S, Pinol M, Canadas MP, Llatjos M, Ballesteros AL, et al. High prevalence of human papillomavirus infection in the anus, penis and mouth in HIV-positive men. AIDS. 2006;20(8):1201–4.

    Article  PubMed  Google Scholar 

  29. Giuliano AR, Lee JH, Fulp W, Villa LL, Lazcano E, Papenfuss MR, et al. Incidence and clearance of genital human papillomavirus infection in men (HIM): a cohort study. Lancet. 2011;377(9769):932–40.

    Article  PubMed  Google Scholar 

  30. Nielson CM, Harris RB, Dunne EF, Abrahamsen M, Papenfuss MR, Flores R, et al. Risk factors for anogenital human papillomavirus infection in men. J Infect Dis. 2007;196(8):1137–45.

    Article  PubMed  Google Scholar 

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Acknowledgments

We thank all study participants. We are grateful to our laboratory staff: Lin-Wun Mao, Ya-Li Wang and Wen-Jai Chang.

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Authors and Affiliations

  1. Department of Nursing, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan

    Chien-Tai Yu, Hsiao-Ying Liu, Yi-Yin Lai & Nai-Ying Ko

  2. Department of Dermatology, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan

    Sheau-Chiou Chao

  3. Department of Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan

    Hsin-Chun Lee, Wen-Chien Ko, Nan-Yao Lee & Chia-Ming Chang

  4. Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan

    Cheng-Yang Chou

  5. Department of Nursing, Buddhist Tzu Chi Medical Center, Hualien, Taiwan

    Chien-Tai Yu

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  1. Chien-Tai Yu
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Correspondence to Nai-Ying Ko.

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Yu, CT., Chao, SC., Lee, HC. et al. High Prevalence of Anal Human Papillomavirus Infection and Associated Risky Behaviors in Men Infected with Human Immunodeficiency Virus in Taiwan. AIDS Behav 17, 1211–1218 (2013). https://doi.org/10.1007/s10461-012-0173-6

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  • DOI: https://doi.org/10.1007/s10461-012-0173-6

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