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Association Between Use of Specific Drugs and Antiretroviral Adherence: Findings from MACH 14

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Abstract

To determine the association between individual substances of abuse and antiretroviral adherence, analyses require a large sample assessed using electronic data monitoring (EDM). In this analysis, EDM data from 1,636 participants in 12 US adherence-focused studies were analyzed to determine the associations between recent use of various substances and adherence during the preceding 4 weeks. In bivariate analyses comparing adherence among patients who had used a specific substance to those who had not, adherence was significantly lower among those who had recently used cocaine, other stimulants or heroin but not among those who had used cannabis or alcohol. In multivariate analyses controlling for sociodemographics, amount of alcohol use and recent use of any alcohol, cocaine, other stimulants and heroin each was significantly negatively associated with adherence. The significant associations of cocaine, other stimulants, heroin, and alcohol use with adherence suggest that these are important substances to target with adherence-focused interventions.

Resumen

Para determinar la asociación entre las distintas sustancias de abuso y de la adherencia antirretroviral, el análisis requiere una gran muestra evaluada mediante el control electrónico de datos (EDM). En este análisis, los datos de EDM de 1,636 participantes en 12 estudios de investigación de EE.UU. centrado en la adhesión fueron analizados para determinar la asociación entre el uso reciente de varias sustancias y la adhesión durante las cuatro semanas anteriores. En el análisis bivariado comparando la adherencia entre los pacientes que habían consumido una sustancia específica para los que no, la adhesión fue significativamente menor entre aquellos que habían consumido recientemente cocaína, otros estimulantes o heroína, pero no entre aquellos que habían consumido cannabis o alcohol. En el análisis multivariante controlando por las características sociodemográficas, la cantidad de consumo de alcohol y el uso reciente de cualquier tipo de alcohol, cocaína, otros estimulantes y heroína, cada uno fue significativa y negativamente asociados con la adherencia. Las asociaciones de cocaína, otros estimulantes, la heroína y el consumo de alcohol con la adhesión sugieren que estas sustancias son importantes para apuntar con la adhesión centrado las intervenciones.

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Acknowledgments

This research was supported by the multi-site adherence collaboration in HIV (MACH14) grant R01MH078773 from the National Institute of Mental Health (NIMH), Office on AIDS. We would like to thank all the patients who participated in each of the individual studies. The content of the paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

  1. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

    M. I. Rosen & A. C. Black

  2. VA Connecticut Healthcare System, West Haven, CT, USA

    M. I. Rosen & A. C. Black

  3. Department of Medicine and Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine and Montefiore Medical Center, Einstein/Montefiore Center for AIDS Research, Bronx, New York, NY, USA

    J. H. Arnsten

  4. Department of Psychology, University of Missouri-Kansas City, Kansas City, MO, USA

    K. Goggin

  5. HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, Columbia University, New York, NY, USA

    R. H. Remien

  6. Department of Psychology, University of Washington, Seattle, WA, USA

    J. M. Simoni

  7. UNC Department of Medicine and Department of Health Behavior and Health Education, UNC Center for AIDS Research; Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC, USA

    C. E. Golin

  8. Mbarara University of Science and Technology, Boston, MA, USA

    D. R. Bangsberg

  9. Harvard Medical School, Boston, MA, USA

    D. R. Bangsberg

  10. Ragon Institute of MGH, Harvard, and MIT, Boston, MA, USA

    D. R. Bangsberg

  11. Center for Global Health, Massachusetts General Hospital, Boston, MA, USA

    D. R. Bangsberg

  12. Division of Public Health and Community Dentistry, School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA

    H. Liu

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  1. M. I. Rosen
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  2. A. C. Black
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  3. J. H. Arnsten
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  4. K. Goggin
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  5. R. H. Remien
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  7. C. E. Golin
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  8. D. R. Bangsberg
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  9. H. Liu
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Corresponding author

Correspondence to M. I. Rosen.

Additional information

This study was conducted on the behalf of MACH14 Investigators.

The details of investigators studies are given in the Appendix.

Appendix

Appendix

The original grants of individual participating studies are: R01DA11869, R01MH54907, R01NR04749, R01NR04749, R01MH68197, R01DA13826, K23MH01862, R01MH01584, R01AI41413, R01 MH61173, NIH/NIAID AI38858, AI069419, K02DA017277, R01DA15215, NIMH P01MH49548, R01MH58986, R01MH61695, CC99-SD003, CC02-SD-003 and R01DA015679.

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Rosen, M.I., Black, A.C., Arnsten, J.H. et al. Association Between Use of Specific Drugs and Antiretroviral Adherence: Findings from MACH 14. AIDS Behav 17, 142–147 (2013). https://doi.org/10.1007/s10461-011-0124-7

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  • DOI: https://doi.org/10.1007/s10461-011-0124-7

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