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Cigarette Smoking and Mortality Among HIV-Infected Individuals in Seattle, Washington (1996–2008)

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Abstract

HIV-infected individuals with access to highly active antiretroviral therapy (HAART) are living longer and the causes of excess morbidity and mortality among people living with HIV/AIDS (PLWHA) are becoming comparable to individuals without HIV infection. However, many PLWHA smoke cigarettes—a well known contributor to excess morbidity and mortality. To investigate the association between smoking and mortality among PLWHA during the HAART era (1996+), we conducted a retrospective cohort study of 2,108 PLWHA enrolled in Seattle and King County’s Adult and Adolescent Spectrum of HIV Disease Study. Adjusted hazard ratios (aHRs) for all-cause and cause-specific mortality were obtained using Cox proportional hazards regression. Compared to never smokers, current smokers (aHR = 1.8, 95% CI: 1.3, 2.3) and individuals with an increased dose and/or duration of smoking were at greater risk of all-cause mortality. Although additional research is needed to evaluate the full effect of smoking on cause-specific mortality, smoking cessation programs should target PLWHA to further increase their life expectancy.

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Acknowledgements

We wish to acknowledge Jim Kent and Amy Bennett from Public Health Seattle & King County for their assistance in creating the final dataset.

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Authors and Affiliations

  1. Department of Epidemiology, University of Washington, P.O. Box 357236, Seattle, WA, 98195, USA

    Heather Pines

  2. Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA

    Laura Koutsky & Susan Buskin

  3. HIV/AIDS Program, Public Health Seattle & King County, Seattle, WA, USA

    Susan Buskin

Authors
  1. Heather Pines
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  2. Laura Koutsky
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  3. Susan Buskin
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Correspondence to Heather Pines.

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Pines, H., Koutsky, L. & Buskin, S. Cigarette Smoking and Mortality Among HIV-Infected Individuals in Seattle, Washington (1996–2008). AIDS Behav 15, 243–251 (2011). https://doi.org/10.1007/s10461-010-9682-3

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  • DOI: https://doi.org/10.1007/s10461-010-9682-3

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