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The role of endoglin in post-ischemic revascularization

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Abstract

Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling preexisting collateral arterioles into physiologically relevant arteries (collateral development). All these processes result in the recovery of organ perfusion. The importance of endoglin in post-occlusion reperfusion is sustained by several observations: (1) endoglin expression is increased in vessels showing active angiogenesis/remodeling; (2) genetic endoglin haploinsufficiency in humans causes deficient angiogenesis; and (3) the reduction of endoglin expression by gene disruption or the administration of endoglin-neutralizing antibodies reduces angiogenesis and revascularization. However, the precise role of endoglin in the several processes associated with revascularization has not been completely elucidated and, in some cases, the function ascribed to endoglin by different authors is controversial. The purpose of this review is to organize in a critical way the information available for the role of endoglin in several phenomena (angiogenesis, arteriogenesis and collateral development) associated with post-ischemic revascularization.

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Authors and Affiliations

  1. Renal and Cardiovascular Research Unit, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain

    Elena Núñez-Gómez, Miguel Pericacho, Claudia Ollauri-Ibáñez & José M. López-Novoa

  2. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain

    Elena Núñez-Gómez, Miguel Pericacho, Claudia Ollauri-Ibáñez & José M. López-Novoa

  3. Centro de Investigaciones Biológicas, Spanish National Research Council (CIB, CSIC), Madrid, Spain

    Carmelo Bernabéu

  4. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain

    Carmelo Bernabéu

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  1. Elena Núñez-Gómez
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Núñez-Gómez, E., Pericacho, M., Ollauri-Ibáñez, C. et al. The role of endoglin in post-ischemic revascularization. Angiogenesis 20, 1–24 (2017). https://doi.org/10.1007/s10456-016-9535-4

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