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Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis

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Abstract

Background

Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial.

Method

To systematically investigate the roles of VM in cancer progression and its prognostic values, we performed a meta-analysis based on 36 studies (33 eligible articles) including 3609 patients. The pooled hazard ratios (HRs) with 95 % confidence intervals (95 % CIs) were used to assess the relationship between VM and overall survival in cancer patients.

Results

Vasculogenic mimicry was significantly associated with cancer differentiation, lymph node metastasis, distant metastasis, and TNM stage. The prognostic value of VM was significant in overall survival (HR 2.16; 95 % CI 1.98–2.38; P < 0.001). Analyses stratified by confounders, such as cancer type, ethnicity, VM detection methods, sample size, and Newcastle–Ottawa quality score, found similar significant results.

Conclusions

The presence of VM predicts poorer survival outcomes in cancer patients.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (Nos. 81472386, 81272340, and 81572901), the National High Technology Research and Development Program of China (863 Program) (No. 2012AA02A501), and the Science and Technology Planning Project of Guangdong Province, China (Grant Nos. 2014B020212017 and 2014A020209024).

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    Authors and Affiliations

    1. State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Rd, Guangzhou, Guangdong, 510060, People’s Republic of China

      J. P. Yang, D. M. Mai, P. Xie, Y. Y. Qiang, L. S. Zheng, M. Y. Wang, Y. Mei, D. F. Meng, L. Xu, L. Cao, Q. Yang, L. X. Peng, B. J. Huang & C. N. Qian

    2. Department of Hepatobiliary Oncology, Affiliated Tumor Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510095, People’s Republic of China

      Y. D. Liao

    3. Department of Chemo-Radiotherapy Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, 430071, People’s Republic of China

      X. X. Yang & W. B. Wang

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    Correspondence to C. N. Qian.

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    J. P. Yang, Y. D. Liao and D. M. Mai have contributed equally to this work and should be considered as co-first authors.

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    Yang, J.P., Liao, Y.D., Mai, D.M. et al. Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis. Angiogenesis 19, 191–200 (2016). https://doi.org/10.1007/s10456-016-9500-2

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