Skip to main content
SpringerLink
Log in

Coupling Chromatography and Crystallization for Efficient Separations of Isomers

  • Published:
Adsorption Aims and scope Submit manuscript

Abstract

Within the pharmaceutical industry and in biotechnology there is an increasing need for selective and efficient separation technologies to isolate and purify value-added products. A hybrid process approach combining chromatography and fractional crystallization is studied below. The work presented is concerned with the application and evaluation of this concept in order to isolate a certain pharmaceutical intermediate from a binary mixture. A comparison with performing the same separation exclusively in a single chromatographic process is given also.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Crosby, J., in Chirality in Industry II, A.N. Collins, G.N. Sheldrake, and J. Crosby (Eds.), pp. 1–10, John Wiley & Sons, Chichester, 1997.

    Google Scholar 

  • Golshan-Shirazi, S. and G. Guiochon, J. Chromatogr. A, 658, 149–171 (1994).

    Article  Google Scholar 

  • Heuer, C., H. Kniep, T. Falk, and A. Seidel-Morgenstern, Chem. Eng. Technol., 21, 469–477 (1998).

    Article  Google Scholar 

  • Jacques, J., A. Collet, and S.H. Wilen, Enantiomers, Racemates and Resolutions, Krieger, Malabar, 1994.

    Google Scholar 

  • Kaspereit, M., P. Jandera, M. Skavrada, and A. Seidel-Morgenstern, J. Chromatogr. A, 944, 249–262 (2002).

    Article  PubMed  Google Scholar 

  • Lim, B.G., C.B. Ching, R.B.H. Tan, and S.C. Ng, Chem. Eng. Sci., 50, 2289–2298 (1995).

    Article  Google Scholar 

  • Lisec, O., P. Hugo, and Seidel-Morgenstern, J. Chromatogr. A, 908, 19–34 (2001).

    Article  PubMed  Google Scholar 

  • Lorenz, H., P. Sheehan, and A. Seidel-Morgenstern, J. Chromatogr. A, 908, 201–214 (2001).

    Article  PubMed  Google Scholar 

  • Mazzotti, M., G. Storti, and M. Morbidelli, J. Chromatogr. A, 769, 3–24 (1997).

    Article  Google Scholar 

  • Mersmann, A., Crystallization Technology Handbook, A. Mersmann (Ed.), pp. 1–78, Marcel Dekker, New York, 1995.

    Google Scholar 

  • Nicoud, R.M., G. Fuchs, P. Adam, M. Bailly, E. Küsters, F.D. Antia, R. Reuille, and E. Schmid, Chirality, 5, 267–271 (1993).

    Article  Google Scholar 

  • Ruthven, D.M. and C.B. Ching, Chem. Eng. Sci., 44, 1011–1038 (1989).

    Article  Google Scholar 

  • Schulte, M. and J. Strube, J. Chromatogr. A, 906, 399–416 (2001).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Otto-von-Guericke-University, IVT, Universitätsplatz 2, 39106, Magdeburg, Germany

    Knut Gedicke

  2. Schering Aktiengesellschaft, Verfahrenstechnik, Müllerstr. 178, 13342, Berlin, Germany

    Wolfgang Beckmann & Andreas Brandt

  3. Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106, Magdeburg, Germany

    Dragomir Sapoundjiev & Heike Lorenz

  4. Schering Aktiengesellschaft, Verfahrenstechnik, Müllerstr. 178, 13342, Berlin, Germany

    Uwe Budde

  5. Otto-von-Guericke-University, IVT, Universitätsplatz 2, 39106, Magdeburg, Germany

    Andreas Seidel-Morgenstern

  6. Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106, Magdeburg, Germany

    Andreas Seidel-Morgenstern

Authors
  1. Knut Gedicke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wolfgang Beckmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andreas Brandt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dragomir Sapoundjiev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Heike Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Uwe Budde
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andreas Seidel-Morgenstern
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Knut Gedicke.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gedicke, K., Beckmann, W., Brandt, A. et al. Coupling Chromatography and Crystallization for Efficient Separations of Isomers. Adsorption 11 (Suppl 1), 591–596 (2005). https://doi.org/10.1007/s10450-005-5990-8

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10450-005-5990-8

Keywords

Search

Navigation