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Mechanical Properties of Porcine Brain Tissue in the Coronal Plane: Interregional Variations of the Corona Radiata

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Abstract

Most biomechanical models that aim to investigate traumatic brain injury consider the corona radiata as a homogeneous structure. To verify this, indentation–relaxation tests using a custom-designed indentation device were performed on the anterior, superior, and posterior region of the corona radiata in the coronal plane of the porcine brain. Using Boltzmann hereditary integral, a linear viscoelastic model with a Prony series approximation was fitted to the time-dependent shear modulus for different regions of the corona radiata, and the fit parameters were generated. The posterior region was the stiffest and the anterior region was the least stiff. A statistical analysis revealed a significant difference in biomedical properties between the anterior and superior regions, as well as between the anterior and posterior regions in the short time scale. However, the results showed that these differences faded away as the tissue approached equilibrium. No significant difference was observed between the superior and posterior regions along the total time history of relaxation. This is the first demonstration of the regional biomechanical heterogeneity of the corona radiata, and these results will improve future biomedical models of the porcine brain.

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Acknowledgments

The authors thank Dr. Fei Gao and Dr. Xiaochen Wang for assistance with the slicing of porcine brain tissue and Dr. Qinhe Zhang and Dr. Renzhi Zhan for use of laboratory equipment. This research was supported financially by the National Natural Science Foundation of China (Grant No. 51375268) and the Independent Innovation Foundation of Shandong University (Grant No. 2012ZD009).

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No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

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Authors and Affiliations

  1. School of Mechanical Engineering, Shandong University, Jinan, 250061, China

    Fuqian Chen, Jun Zhou, Yan Li, Yongbo Wang, Lihong Li & Hongzhi Yue

  2. Key Laboratory of High Efficiency and Clean Mechanical Manufacture (Shandong University), Ministry of Education, Jinan, 250061, China

    Fuqian Chen, Jun Zhou, Yan Li, Yongbo Wang, Lihong Li & Hongzhi Yue

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  1. Fuqian Chen
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  2. Jun Zhou
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Correspondence to Jun Zhou.

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Associate Editor Eiji Tanaka oversaw the review of this article.

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Chen, F., Zhou, J., Li, Y. et al. Mechanical Properties of Porcine Brain Tissue in the Coronal Plane: Interregional Variations of the Corona Radiata. Ann Biomed Eng 43, 2903–2910 (2015). https://doi.org/10.1007/s10439-015-1350-3

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