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Tissue Engineering and Regenerative Repair in Wound Healing

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Abstract

Wound healing is a highly evolved defense mechanism against infection and further injury. It is a complex process involving multiple cell types and biological pathways. Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation. In contrast, early to mid-gestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation. This early observation has led to extensive research seeking to unlock the mechanism underlying fetal scarless regenerative repair. Building upon recent advances in biomaterials and stem cell applications, tissue engineering approaches are working towards a recapitulation of this phenomenon. In this review, we describe the elements that distinguish fetal scarless and adult scarring wound healing, and discuss current trends in tissue engineering aimed at achieving scarless tissue regeneration.

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Acknowledgments

The authors thank Ingrid Lai and William Shu for their generous gift support of this work. This work was supported in part by a grant from NIH grant R01 GM087609 (to H.P.L.).

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The authors declare no conflicts of interest.

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  1. Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA, 94305-5148, USA

    Michael S. Hu, Zeshaan N. Maan, Jen-Chieh Wu, Robert C. Rennert, Wan Xing Hong, Alexander T. M. Cheung, Graham G. Walmsley, Michael T. Chung, Adrian McArdle, Michael T. Longaker & H. Peter Lorenz

  2. Department of Surgery, John A. Burns School of Medicine, University of Hawai’i, Honolulu, HI, USA

    Michael S. Hu

  3. Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    Tiffany S. Lai

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  1. Michael S. Hu
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Associate Editor Scott I Simon oversaw the review of this article.

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Hu, M.S., Maan, Z.N., Wu, JC. et al. Tissue Engineering and Regenerative Repair in Wound Healing. Ann Biomed Eng 42, 1494–1507 (2014). https://doi.org/10.1007/s10439-014-1010-z

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