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Can Molecular Imaging Enable Personalized Diagnostics? An Example Using Magnetomotive Photoacoustic Imaging

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A Commentary to this article was published on 08 February 2014

Abstract

The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering and absorption remains a big challenge. For example, differentiating circulating tumor cells in vivo (typically fewer than 10 cells/mL for an active tumor) among billions of erythrocytes in the blood is nearly impossible. In this paper, a newly developed technique, magnetomotive photoacoustic (mmPA) imaging, which can greatly increase the sensitivity and specificity of sensing targeted cells or molecular interactions, is reviewed. Its primary advantage is suppression of background signals through magnetic enrichment/manipulation with simultaneous PA detection of magnetic contrast agent targeted objects. Results from phantom and in vitro studies demonstrate the capability of mmPA imaging to differentiate regions targeted with magnetic nanoparticles from the background, and to trap and sensitively detect targeted cells at a concentration of a single cell per milliliter in a flow system mimicking a human peripheral artery. This technique provides an example of the ways in which molecular imaging can potentially enable robust molecular diagnosis and treatment, and accelerate the translation of molecular medicine into the clinic.

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Acknowledgments

This work was supported in part by NIH RO1EB016034, RO1CA170734, RO1CA131797, R01CA140295, T32CA138312, NSF 0645080, the Life Sciences Discovery Fund 3292512, and the Department of Bioengineering at the University of Washington.

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Authors and Affiliations

  1. Department of Bioengineering, University of Washington, 3720, 15th Ave NE, Seattle, WA, 98195, USA

    Matthew O’Donnell, Chen-wei Wei, Jinjun Xia, Ivan Pelivanov, Congxian Jia, Sheng-Wen Huang, Xiaoge Hu & Xiaohu Gao

  2. M.V. Lomonosov Moscow State University, Leninskie Gory, 1, bld. 2, 119991, Moscow, Russia

    Ivan Pelivanov

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  1. Matthew O’Donnell
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  2. Chen-wei Wei
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Correspondence to Chen-wei Wei.

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Associate Editor James Tunnell oversaw the review of this article.

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O’Donnell, M., Wei, Cw., Xia, J. et al. Can Molecular Imaging Enable Personalized Diagnostics? An Example Using Magnetomotive Photoacoustic Imaging. Ann Biomed Eng 41, 2237–2247 (2013). https://doi.org/10.1007/s10439-013-0901-8

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  • DOI: https://doi.org/10.1007/s10439-013-0901-8

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